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EC number: 401-700-2 | CAS number: 3100-36-5 CYCLOHEXADECENON; CYCLOHEXADECENONE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-08-12 to 1987-03-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- According to OECD 402 and GLP, but individual animal results not provided in the report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- According to OECD 402 and GLP, but individual animal results not provided in the report.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of cis- and trans-cyclohexadec-8-en-1-one
- EC Number:
- 401-700-2
- EC Name:
- A mixture of cis- and trans-cyclohexadec-8-en-1-one
- Cas Number:
- 3100-36-5
- Molecular formula:
- C16H28O
- IUPAC Name:
- (8E)-cyclohexadec-8-en-1-one; (8Z)-cyclohexadec-8-en-1-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Albino rabbits
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: Yes
- Rationale for use of males: Both sexes were investigated
- Age at study initiation: Young adult
- Weight at study initiation: 2.0 - 3.0 kg
- Housing: Individually in suspended, galvanized cages, fitted with wire-mesh floor and front. Throughout the 24-hour exposure period the animals were kept in restraining boxes.
- Diet: Ad libitum (standard laboratory rabbit diet), except for 24 hours exposure period
- Water: Ad libitum
- Acclimation period: Approx. 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): At least 40
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From day 0 to day 15
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- The test substance was melted at approx. 35°C
- Details on dermal exposure:
- TEST SITE
- % coverage: Approx. 10
- Type of wrap used: The treated skin area of the rabbits was covered with a thin layer of cellulose sheet and wrapped in polyethylene foil.
REMOVAL OF TEST SUBSTANCE
- Washing: Residual test substance was removed from the skin with an appropriate solvent.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount applied: 5 mL/kg bw
- Concentration: The test substance was applied in pure form
- Constant volume or concentration used: No - Duration of exposure:
- 24 hours
- Doses:
- 5 mL/kg bw
- No. of animals per sex per dose:
- 5 animals per sex were treated with a single dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights were recorded on day 0 (day of dosing), 8 and 15 (day of autopsy). Mortality was recorded with the time and cause of death as precisely as possible.
- Necropsy of survivors performed: Yes
- Clinical signs including body weight: All visible reactions to treatment observed during the 24-hour exposure period and during the subsequent two-week period were recorded.
- Other examinations performed: Clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No rabbits died during the 24-hour exposure period. On day 2, one rabbit was found dead.
- Clinical signs:
- other: Local effects: During and/or at the end of the 24-hour exposure period treatment-related dermal effects consisted of slight erythema and slight oedema. The following local skin reactions were recorded for all rabbits during the 14-day observation period:
- Gross pathology:
- The autopsy findings in all animals (also in the animal that died) were normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo acute dermal toxicity study in rabbits according to OECD guideline 402, the LD50 was higher than 4600 mg/kg bw.
- Executive summary:
A sample of the test substance was examined for its acute dermal toxicity in a limit test with albino rabbits according to OECD guideline 402 and GLP. Five male and five female rabbits were dermally treated with 5.0 mL/kg body weight. The exposure period was 24 hours. Acute local skin reactions consisted of slight erythema and slight oedema. At the end of week 1, moderate to severe scaliness and some slight incrustation were observed, and at the end of week 2 (at autopsy), slight to severe scaliness. The only sign of acute toxicity consisted of slight apathy which was observed in two rabbits. One male rabbit died but autopsy findings were normal. There was some growth retardation during week 1 but during week 2, growth was normal. Apart from the slight local skin effects mentioned above, terminal autopsy findings were normal. On the basis of the results obtained, it was concluded that the substance is not considered to be harmful in contact with skin, the dermal LD50 value being higher than 4600 mg/kg bw (5.0 mL/kg bw).
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