platinum(IV) nitrate/nitric acid solution

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP, guideline study, acceptable without restriction.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1999

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Principles of method if other than guideline:

Testing was carried out using a modified procedure as the test material is a solution in concentrated nitric acid for which a substance-specific analytical method was unavailable.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

432-400-1

EC Name:

-

Cas Number:

10102-09-7

Molecular formula:

[Pt(NO3)x(OH)y]H2 where x = 2-5, y = 4-1, and x + y = 6

IUPAC Name:

platinum(4+) dihydrate tetranitrate

Test material form:

other: liquid

Details on test material:

The test material was in nitric acid and non-isolatable

Radiolabelling:

no

Study design

Analytical monitoring:

no

Details on test conditions:

Aliquots of test material were diluted with glass double-distilled water, stored in a water bath at 50.0 +/- 0.5°C, and shielded from light.

Duration of test

Duration:

5 d

Number of replicates:

Five

Positive controls:

no

Negative controls:

no

Results and discussion

Transformation products:

yes

Identity of transformation products

No.:

#1

Reference

Reference substance name:

Unnamed

IUPAC name:

hexahydroxy platinic acid

Identifier:

common name

Identity:

hexahydroxy platinic acid

Details on hydrolysis and appearance of transformation product(s):

Hydrolysis was assessed by visual estimation of the formation of hexahydroxy platinic acid, an orange-brown solid formed when the molar ratio of nitric acid to platinum in Platinum (VI) Nitrate is reduced below 8:1.

Dissipation DT50 of parent compound

Temp.:

25 °C

DT50:

> 0 - < 1 d

Remarks on result:

other: at 4 times or greater dilution with water

Details on results:

Hydrolytic stability decreases with increasing dilution with water. At 4 times dilution or greater, the half-life is less than 1 day at 25°C.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

Hydrolytic stability decreases with increasing dilution with water. At 4 times dilution or greater, the half-life of Platinum (IV) Nitrate in nitric acid was less than 1 day at 25°C.

Executive summary:

In a GLP, guideline study the half-life of Platinum (IV) Nitrate in nitric acid was less than 1 day at 25°C, at 4 times or greater dilution with water. This study is considered reliable and acceptable for use as key study for this endpoint.