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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Based on the harmonised classification under Annex VI of the CLP Regulation (EC) No. 1272/2008 (index no. 604 -006 -00 -x, ATP0), the test substance is considered to be toxic via oral and dermal routes.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Key result
Dose descriptor:
LD50
Remarks:
Rat
Effect level:
3 200 mg/kg bw
Based on:
test mat.
95% CL:
2 780 - 3 680
Remarks on result:
other: apathy, lying on the side, respiratory arrest (no further details)
Remarks:
LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
Key result
Dose descriptor:
LD50
Remarks:
Mouse
Effect level:
809 mg/kg bw
Based on:
test mat.
95% CL:
724 - 914
Remarks on result:
other: apthy, lying on the side, respiratory arrest
Remarks:
LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
Key result
Dose descriptor:
LD50
Remarks:
Mouse
Effect level:
> 1 000 - <= 1 250 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no deaths; curved position and reeling at 1000 mg/kg bw/day; deaths at 1250 mg/kg bw
Remarks:
LD50 value from BASF, 1998b study cited in BG RCI, 2005 report
Interpretation of results:
study cannot be used for classification
Conclusions:
Based on literature sources, the LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice.
Executive summary:

The BG RCI report on test substance reported three acute toxicity studies conducted in rats and mice. The LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice (BG RCI, 2005).

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Endpoint:
acute toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Reason / purpose for cross-reference:
data waiving: supporting information
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 250 mg/kg bw
Quality of whole database:
Literature data cited in BG RCI report

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Data waiving: In accordance with Annex VII, Section 8.5, Column 2, an acute toxicity study does not need to be conducted because the substance is classified as corrosive to the skin.   

Literature data available on the test substance reported the LD50 values as 3500 mg/kg bw in rats and 809 to 1250 mg/kg bw/day in mice (BG RCI, 2005).

Justification for classification or non-classification

The test substance has a ‘Acute Tox. 3 ; H301: Toxic if swallowed' and 'Acute Tox. 3; H11: Toxic in contact with skin' harmonised classification under the EU CLP (Regulation EC 1272/2008).