OligoActiv EDDHA-Mn

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01 MAR 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Decomposition:

yes

Decomp. temp.:

>= 92.38 - <= 182.42 °C

Remarks on result:

not determinable

Pre-test for melting point

The following observations were recorded:

From 150 °C: The test substance was slightly shrivelled with condensate

From 320 °C: The colour was darker

From 349 °C: The colour was nearly black

Up to 360 °C: The test substance was black and shrivelled, no signs of melting were observed, decomposition was considered.

After cooling down: The test substance stayed as a compacted solid

Selected temperature was 360 °C, the capillary tube containing the test substance was set into channel 2 of the instrument at 21.0 °C

In the additionally pre-test on a magnesia groove with the gas burner, the test substance shrivelled, charred and glowed.

Security Pre-test for the DSC instrument

The lid of the crucible was bloated after reaching a temperature of 600 °C. The weight was recorded with 33.46 mg.

Calibration

The measurement of indium after calibration met the validity criteria.

Observations

	Mass test item	Mass crucible (before measurement):	Mass crucible (after measurement):	Observations
First Measurement	1.62 mg	34.19 mg	33.61	After the test the crucible was bloated. The crucible was opened, the test substance stayed as a black powder, decomposition was considered.
Second Measurement	1.63 mg	34.03 mg	33.44	After the test the crucible was bloated.

Interpretation of the measurements

Two DSC measurements were performed.

In the first measurement, an unsteady baseline between 100.02 °C and 165.03 °C was detected.

In the second measurement an exothermic event from 92.38 °C to 182.42 °C with an unsteady baseline was detected.

The unsteady baseline and exothermic event could be signs of decomposition, as the condensate was seen in the pre-test and the test substance had shrivelled slightly, as well as the colour change.

Therefore, no melting point can be given under these test conditions as the test item has decomposed.

The decomposition process is given in the range of 92.38 °C - 182.42 °C.

Assessment

The DSC measurement of indium after calibration met the validity criteria.

Therefore, the result of the study is considered valid.

FINAL RESULT

The determination of the melting point of the sample was performed via DSC (differential scanning calorimetry.

Based on the observation in the pre-test the decomposition process is given in the range of 92.38 °C - 182.42 °C.

The measurement of indium after calibration met the validity criteria. Therefore, the result of the study is considered valid.

Conclusions:

Based on the observation in the pre-test the decomposition process is given in the range of 92.38 °C - 182.42 °C.

Executive summary:

The determination of the melting point of the test item was performed via DSC (differential scanning calorimetry) according to OECD Guideline 102 and EU Method A.1.

 

Based on the observation in the pre-test the decomposition process is given in the range of 92.38 °C - 182.42 °C. No melting was observed.

Description of key information

The determination of the melting point of the test item was performed via DSC (differential scanning calorimetry) according to OECD Guideline 102 and EU Method A.1.

 

Based on the observation in the pre-test the decomposition process is given in the range of 92.38 °C - 182.42 °C. No melting was observed.