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EC number: 421-090-1 | CAS number: 131298-44-7 Isodecyl benzoate
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06/09/1987 - 06/23/1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP run study following Guideline EPA OPP 81-2.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 421-090-1
- EC Name:
- -
- Cas Number:
- 131298-44-7
- Molecular formula:
- C17H26O2
- IUPAC Name:
- undecyl benzoate
- Reference substance name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- IUPAC Name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- Reference substance name:
- Isodecyl benzoate
- IUPAC Name:
- Isodecyl benzoate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult (~14 weeks of age) New Zealand White rabbits were procured from Hazleton Research Products, Inc, maintained individually in screen-bottom cages suspended over absorbant pan liners for urine and feces collection, in temperature and humidity controlled quarters (19 - 23 degrees C and 36-66 % RH), provided access to water ad libitum, and a measured amount of Purina High fiber Rabbit Chow. The annimals were held for an acclimation period of at least 7 days. Animal husbandry and housing at HLA complied with standards outlined in the "Guide for the Care and Use of Laboratory Animals." Test animals were uniquely identified by animal number and corresponding ear tag.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approximately 24 hours before test material application, each rabbit's back was shaved with an electric clipper. The shaved area made up approximately 20% of the total body surface. The test material was applied to each animal's back at a dosage level of 2.0 g/kg. The area of application was covered with a 10 x 10 cm gauze patch secured with paper tape and overwrapped with Saran Wrap and Elastoplast tape. Twenty-four hours later the bandages were removed and the backs were washed with lukewarm tap water and wiped with disposable paper towels. Collars were applied to restrain the test animals during the twenty-four hour exposure period.
- Duration of exposure:
- 24 hours
- Doses:
- 2.0 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Following exposure, the animals were observed for clinical signs and mortality at 1, 2.5 and 4 hours after test material administration. Thirty minutes after removal of the test material the initial dermal irritation reading was made. Subsequent readings of dermal irritation were made on study days 3, 7, 10, and 14. The animals were observed daily for clinical signs and twice daily (morning and afternoon) for mortality. The animals were weighed just prior to test material application, at 7 days, and at study termination.
- Statistics:
- Other than averaging body weights, no other statistical method was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- No mortality was seen throughout the duration of the study.
- Clinical signs:
- other: Only one animal showed a clinical effect of holding its head to the left from day 7 through day 14 of observations.
- Gross pathology:
- No visible lesions were found when the animals were examined postmortem.
- Other findings:
- Dermal irritation consisted of slight to moderate erythema, edma, and desquamation, and slight atonia, coriaceousness and fissuring.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test material Isodecyl Benzoate was evaluated for its dermal toxicity potential in male and female rabbits. The estimated dermal LD50 is greater than 2.0 g/kg of body weight.
- Executive summary:
Isodecyl Benzoate was evaluated for dermal toxicity potential in 5 male and 5 female young adult New Zealand White rabbits according to the EPA OPP 81-2 Acute Dermal Toxicity protocol. Approximately 24 hours before test material application, each rabbit's back was shaved with an electric clipper. The shaved area made up approximately 20% of the total body surface. The test material was applied to each animal's back at a dosage level of 2.0 g/kg. The area of application was covered with a 10 x 10 cm gauze patch secured with paper tape and overwrapped with Saran Wrap and Elastoplast tape. Twenty-four hours later the bandages were removed and the backs were washed with lukewarm tap water and wiped with disposable paper towels. Collars were applied to restrain the test animals during the twenty-four hour exposure period. Following exposure, the animals were observed for clinical signs and mortality at 1, 2.5 and 4 hours after test material administration. Thirty minutes after removal of the test material the initial dermal irritation reading was made. Subsequent readings of dermal irritation were made on study days 3, 7, 10, and 14. The animals were observed daily for clinical signs and twice daily (morning and afternoon) for mortality. The animals were weighed just prior to test material application, at 7 days, and at study termination. Clinically, dermal irritation consisted of slight to moderate erythema, edma, and desquamation, and slight atonia, coriaceousness, and fissuring. No mortality was seen throughout the duration of the study. Only one animal showed a clinical effect of holding its head to the left from day 7 through day 14 of observations. Average Body Weights were for males 2329, 2485, and 2525 grams (, Day 7, and Day 14, respectively) and for females were 2452, 2686, and 2707 grams (Day of dose administration, Day 7, and Day 14, respectively). Gross pathology revealed no visible lesions when the animals were terminated. The estimated dermal LD50 for Isodecyl Benzoate in male and female rabbits is greater than 2.0 g/kg of body weight.
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