Ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

GLP compliance:

yes

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Type:

Pow

Partition coefficient:

11 600

Temp.:

25 °C

Remarks on result:

other: no pH has been reported

Key result

Type:

log Pow

Partition coefficient:

4.07

Temp.:

25 °C

Remarks on result:

other: no pH has been reported

RESULTS

Table 1 Experimental data

sample number	1	2	3	4	5	6
amount of test substance/ mg	24.7008	24.7008	49.2032	50.6912	12.3008	12.2016
volume of octanol /mL	10	10	20	20	5	5
volume of water /mL	50	50	50	50	50	50
concentration of the substance in the octanol phase/ (mg/L)	2508.19	2461.19	2462.15	2512.5	2512.269	2460.61
average of 3 values	2513.23	2459.98	2460.9	2519.14	2514.03	2465.95
	2513.36	2463.32	2447.372	2520.33	2512.56	2466.78
	2511.6	2461.5	2456.8	2517.3	2513	2464.4
concentration of the substance in the aqueous phase/ (mg/L)	218.795	210.538	210.661	212.597	218.213	210.279
average of 3 values	220.816	211.003	210.368	212.458	217.56	210.013
	219.908	211.059	209.913	215.689	218.653	211.549
	219.8	210.9	210.3	213.6	218.1	210.6
amount of substance in octanol phase / mg	25.116	24.615	49.136	50.346	12.565	12.322
amount of substance in water phase / mg	0.011	0.011	0.011	0.011	0.011	0.011
total recovered amount of substance / mg	25.127	24.626	49.147	50.357	12.576	12.333
recovery / %	102	100	100	99	102	101
Pow	11427	11671	11682	11785	11522	11702
average Pow	11549		11734		11612
average Pow ± SD	11632 ± (131)
average log Pow ± SD	4.07 ±0.005

 

Conclusions:

The octanol-water partition coefficient (Log Pow) of the test substance at 25 °C was 4.07 and the Pow 11600 at 25 °C .

Executive summary:

The octanol-water partition coefficient (Log Pow) of the test substance was conducted in accordance with OECD TG 107 and in compliance with GLP. At 25 °C, the octanol-water partition coefficient of test substance was determined to be 4.07 and the Pow 11600.

Description of key information

Log Pow = 4.07 at 25 °C, OECD TG 107, shake flask method, Rodler 1992.

Key value for chemical safety assessment

Log Kow (Log Pow):

4.07

at the temperature of:

25 °C