cyproconazole (ISO); (2RS,3RS;2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Nov 1998 to 26 Nov 1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

27 Jul 1995

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

29 Dec 1992

GLP compliance:

yes

Type of method:

gas saturation method

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

RESULTS

The first experiment at 55°C with nitrogen flow rates of 40, 60 and 80 min/min has shown that the flow rates did not correlate with the transferred amounts of test substance. Therefore, the experiment at 55 °C was repeated with longer collecting times.

In the repetition and all other measurements, the transferred amounts of test substance and vapour pressures now correlated well with the flow rates. The following results were obtained .

Table 2 Vapour pressure results

Temperature [°C]	Nitrogen Flow Rate [mln)	Nitrogen Volume [min]	Volume at Test Temp. [ml]	Substance  [µg]	Vapour Pressure [Pa]
45	40	225600	262766	16.890	5.8E-04
45	60	338400	394150	18.696	4.3E-04
45	80	451200	525533	25.342	4.4E-04
55	40	156000	187411	28.778	1.4E-03
55	60	234000	281117	44.632	1.5E-03
55	80	312000	374823	58.876	1.5E-03
65	40	43200	53480	29.802	5.4E-03
65	60	64800	80220	46.692	5.6E-03
65	80	86400	106960	61.296	5.5E-03
75	40	4800	6118	9.832	1.6E-02
75	60	7200	9177	17.932	1.9E-02
75	80	9600	12236	23.446	1.9E-02

Vapour pressure curve of the test substance in the solid state: 10Log p [Pa] = 5869.9 x 1/T = 15.097

from fit of measurements between 45 and 75°C (r2 = 0.9936)

Vapour pressure at 25 °C: 2.6E-5 (extrapolated from vapour pressure curve)

The obtained results have shown that higher flow rates did not lead to lower vapour pressures which means that complete saturation was achieved in the measured flow range from 40 to 80 mln/min in the temperature range from 45 to 75 °C. The observed differences are within the estimated reproducibility of the method. No test substance was found in the second cooling trap in all experiments which means that the transported test substance was quantitatively condensed in the first cooling trap.

The vapour pressure curve log p [Pa] versus 1/f [K] was found to be linear in the temperature range from 45 °C to 75 °C. It can be concluded from the linearity of the vapour pressure curve that the extrapolated vapour pressure at 25 °C is a reliable value.

No phase change of the test substance was observed in the measured temperature range from 45 °C to 75 °C. In all experiments, the compound was in the solid state.

No problems encountered that could have affected the integrity of the study.

Table 3 Experimental Data for the Vapour Pressure Determination of the test substance

T [°C]	T [K]	1/f [/K]	Nitrogen Flow Rate [mln/min]	Collecting Time [mln]	Volume V 1 of Nitrogen [mln]	Volume V 2 of Nitrogen at the Test Temperature
55^1)	328.15	3.05E-03	40	900	36000	43249
55^1)	328.15	3.05E-03	60	900	54000	64873
55^1)	328.15	3.05E-03	80	900	72000	86498
45	318.15	3.14E-03	40	5640	225600	262766
45	318.15	3.14E-03	60	5640	338400	394150
45	318.15	3.14E-03	80	5640	451200	525533
55	328.15	3.05E-03	40	3900	156000	187411
55	328.15	3.05E-03	60	3900	234000	281117
55	328.15	3.05E-03	80	3900	312000	374823
65	338.15	2.96E-03	40	1080	43200	53480
65	338.15	2.96E-03	60	1080	64800	80220
65	338.15	2.96E-03	80	1080	86400	106960
75	348.15	2.87E-03	40	120	4800	6118
75	348.15	2.87E-03	60	120	7200	9177
75	348.15	2.87E-03	80	120	9600	12236

1) first experiment, data not used for the evaluation of the vapour pressure

Table 4 Vapour Pressure Data of of the test substance

T [°C]	Volume mL	Amount of Test Substance in Cooling Trap 1 (µg]	Amount of Test Substance in Cooling Trap 2 [µg]	Vapour Pressure [Pa]	10log Vapour Pressure	Vapour* Pressure
55^1)	43249	0.712	0	0.0001539	-3.81	1.5E-04
55^1)	64873	5.766	0	0.0008310	-3.08	8.3E-04
55^1)	86498	7.726	0	0.0008351	-3.08	8.4E-04
45	262766	16.890	0	0.0005827	-3.23	5.8E-04
45	394150	18.696	0	0.0004300	-3.37	4.3E-04
45	525533	25.342	0	0.0004371	-3.36	4.4E-04
55	187411	28.778	0	0.0014357	-2.84	1.4E-03
55	281117	44.632	0	0.0014844	-2.83	1.5x 10^-3
55	374823	58.876	0	0.0014686	-2.83	1.5x 10^-3
65	53480	29.802	0	0.0053689	-2.27	5.4x 10^-3
65	80220	46.692	0	0.0056078	-2.25	5.6E-03
65	106960	61.296	0	0.0055213	-2.26	5.5E-03
75	6118	9.832	0	0.0159414	-1.80	1.6E-02
75	9177	17.932	0	0.0193831	-1.71	1.9E-02
75	12236	23.446	0	0.0190074	-1.72	1.9E-02

1) first experiment, data not used for the evaluation of the vapour pressure

* vapour pressure in exponential form, rounded to one figure after the decimal point

Conclusions:

The vapour pressure at 25 °C was found by extrapolation to be 2.6E-5 Pa.

Executive summary:

The vapour pressure of the test substance was determined by the gas saturation method in accordance with the OECD TG 104 and EU Method A.4 and was in compliance with GLP. The vapour pressure of the test substance was determined at 2.6E-5 Pa at 25 °C .

Description of key information

2.6E-5 Pa at 25 °C. OECD TG 104, GC saturation method, Widmer 1998.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C