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EC number: 239-360-0 | CAS number: 15323-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test comprised of an induction treatment of topical applications of a dilution of the test substance with 2% in ethanol followed by UV-irradiation, once daily on 5 consecutive days, and a challenge treatment, 10 days after the last induction consisting of one application with 2% in ethanol followed by UV-irradiation. During the induction phase, ten guinea pigs were treated with the test substance and 5 with ethanol. All animals were challenged with the test substance.
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- skin sensitisation
Test material
- Reference substance name:
- 1,1,2,3,3,6-hexamethylindan-5-yl methyl ketone
- EC Number:
- 239-360-0
- EC Name:
- 1,1,2,3,3,6-hexamethylindan-5-yl methyl ketone
- Cas Number:
- 15323-35-0
- Molecular formula:
- C17H24O
- IUPAC Name:
- 1,1,2,3,3,6-hexamethylindan-5-yl methyl ketone
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Description: white, crystalline solid
Test animals
- Species:
- guinea pig
- Strain:
- other: Cpb:GpHi 65
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Central Institute for the Breeding of Laboratory Animals TNO, Zeist, the Netherlands
- Weight at study initiation: 235-310 g
- Housing: Individually under conventional conditions in suspended, stainless steel cages, fitted with wire mesh floor and front
- Diet: Pelleted, natural ingredient diet (Hope Farms, Woerden, The Netherlands), ad libitum
- Water: Unfluoridated tap water, ad libitum
- Acclimation period: 3 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18±2
- Humidity (%): 40-70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- ethanol
- No. of animals per sex per dose:
- - Test group: 10 - Control group: 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Induction: Induction was effected by topical treatment. For this purpose the dorsal neck region and the mid-dorsal region of the test and control animals were closely shaved with electric clippers. Shaving was repeated before each application or reading if necessary. The treatment consisted of applying 0.2 mL of a 2% solution of the test substance in ethanol (96%) to the dorsal neck region of each test animal once daily for 5 days. At the same time, 0.2 mL solvent was applied, as a control, to the mid-dorsal region of the test animals. The treated sites covered an area of about 2 x 3 cm. Control animals were similarly treated with 0.2 mL solvent only. After each application of the solvent and the test solution, the animals were placed together under a Philips UV fluorescent lamp (40 W/08, F40 T12 BLB, wave length of 310—420 nm), and then irradiated for 30 min at a distance of 37 cm from the lower side of the lamp.
Challenge: Topical challenge was carried out 10 days after the last topical induction as follows: The dorsal neck and mid-dorsal region of the guinea pigg was closely shaved again with electric clippers. Subsequently 0.2 mL of a 2% solution of the the substance in ethanol (96 %) was applied to the dorsal neck region of the test animals as well as of the control animals. At the same time, as a control, 0.2 mL solvent was applied to the mid-dorsal region of each animal. The treated sites covered an area of about 2 x 3 cm. Then all animals were exposed to UV irradiation for 30 min as described before.
Examinations
- Examinations:
- Induction: Skin readings were made 24 h after each daily treatment. The responses were given a score according to Draize et al. (1944).
Challenge: Skin readings were made after 24, 48 and 72 h.
Results and discussion
- Details on results:
- All animals remained in good health during the experimental period. During the five days of the induction period, a number of animals showed very slight erythema on the treated site after the 2nd, 4th and 5th application and irradiation. None of the control sites showed a positive response. Upon the challenge treatment with the 2% dilution of the test substance one out of ten test animals showed very slight erythema after 24, 48 or 72 hours.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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