Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 444-090-3 | CAS number: 204848-45-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20-Jan-2003 to 25-March-2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study (OECD test guideline 202)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted on 17th July 1992
- Deviations:
- yes
- Remarks:
- The softened Elendt M4 solution was adjusted from the description in the Protocol to produce a media with the required hardness to fulfil test guideline requirements.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- adopted on 29th December 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Version / remarks:
- adopted in April 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, Test Data for Registration of Agricultural Chemicals, 12 Nohsan No 8747, 24 November 2000
- Deviations:
- no
- Principles of method if other than guideline:
- The adult mortality recorded in the culture used for this study is slightly greater than the culture mortality recommended in the guidelines. However, the total number in the culture at that time was small, hence the death of two adults appeared disproportional. As the culture fulfilled the guideline criteria in all other aspects, and had been healthy for the previous 25 days, it was considered acceptable for use, and is not considered to have affected the outcome or validity ofthe study.
The softened Elendt M4 solution was adjusted fi-om the description in the Protocol to produce a media with the required hardness to fulfil test guideline requirements. The concentrations of the following ingredients of softened Elendt M4 should read:
CaCl2.2H20 182.16 mg/l
MgS04.7H20 76.45 mg/l
KCl 3.60 mg/l
NaHCOs 40.18 mg/l
Na2Si03.9H20 10.00 mg/l
As survival and reproduction of Daphnia in the stock cultures remained satisfactory, this deviation from Protocol was not considered to have adversely affected the health of the Daphnia, nor the outcome ofthe study. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 444-090-3
- EC Name:
- -
- Cas Number:
- 204848-45-3
- Molecular formula:
- C44 H43 N3 O4
- IUPAC Name:
- Propanoic acid, 2-[4-[4,6-bis([1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-yl]-3-hydroxyphenoxy]-, isooctyl ester
- Details on test material:
- - Appearance: yellow powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method:
80 mg of the test substance was dispersed in 2 L of test medium. Softened Elendt M4, to give a stock dispersion of 40 mg/L.Three replicate vessels were prepared for the control and the test group and measured at 0 and 48 hours.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 80 mg test substance was dispersed in 2 L of test medium, Softened Elendt M4 to give a stock dispersion of 40 mg/L. The dispension was stirred for ca. 70 hours and then filtered through a pre-conditioned 0.45 µm cellulose nitrate filter conditioned to the test substance to give a 100% saturated solution.
- Controls:
Blank water
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Source: strain originating from the Institute National de Rechereche Chimique Appliqué (IRChA), France
- Age at study initiation (mean and range, SD): juvenile, less than 24 hours
- Method of breeding: stock cultures were maintained in glass vessels containing 500-800 mL Softened Elendt M4 culture medium. Cultures were fed daily with a suspension of he unicellular green alga, Chlorella vulgaris.
- Feeding during test: NO
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.6 - 7.7
- Dissolved oxygen:
- 7.7 - 8.0 mg/L
- Nominal and measured concentrations:
- Measured:
1.19 - 2.06 µg/L at 0 hours
7.30 - 7.45 µg/L at 48 hours
geometric mean measured concentration: 3.5 µg/L
Nominal:
100% saturated solution: 40 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass jars
-Fill volume: 250 mL capacity; 200 mL test solution per vessel
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
TEST MEDIUM
- Softened Elendt M4:
CaCl2*2H20 = 182.16 mg/L
MgSO4*7H20 = 76.45 mg/L
KCl = 3.60 mg/L
NaHCO3 = 40.18 mg/L
Na2SiO3*9H2O = 10.00 mg/L
OTHER TEST CONDITIONS
- Photoperiod: lightness/dare = 16/8
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immoblisation (observation: after 24 and 48 hours)
TEST CONCENTRATIONS
- Range finding study: a preliminary range finding test was conducted using test concentrations of 1, 10, and 100% saturated solution. No toxic effects were observed at the max. concentration. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 other: % saturation
- Nominal / measured:
- nominal
- Conc. based on:
- other: saturated solution
- Basis for effect:
- other: immobilisation
- Remarks on result:
- other: No acute toxic effects within the range of solubility.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3.5 µg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: immobilisation
- Remarks on result:
- other: No acute toxic effects within the range of solubility.
- Details on results:
- -No immobilisation was observed during the 48 hour exposure period. Thus, neither the NOEC nor the EC50 of the test item can be calculated because these values are greater than the level of the test item achieved in aqueous solution under the conditions of this test.
- Results with reference substance (positive control):
- - Results with reference substance valid? YES
Time = 24 hr; EC50 = 0.85 mg/L; 95% CL = 0.64-0.98 mg/L
Time = 48 hr; EC50 = 0.73 mg/L; 95% CL = 0.54-0.87 mg/L
Highest test concentration resulting in 0% mortality: 0.32 mg/L
Lowest test concentration resulting in 100% mortality: 3.2 mg/L
No-observed effect concentration: 0.32 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No acute toxic effects occurred within the range of solubility. Therefore, the test substance is with high probability acutely not harmful to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.