Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-477-0 | CAS number: 10193-36-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
The Polyethylene glycol resulted to have a mutagenicity activity against Chinese Hamster epithelial liver cells (CHEL) and Chinese hamster Ovary (CHO).
However, this doesn’t reflect the real behaviour of the PEG 400 which isn’t able to cross the biological membranes. In support of this, the PEG 400 shows a negative Log Kow (-3.05) and for this systemic and local exposures are unlikely. In fact, PEG 400 is widely used in products such as cosmetics and pharmaceuticals.
Concerning the Tetrahydroxy salicylate, a read-across based on the sodium salicylate was approached. As reported in the endpoint “Genetic toxicity in vitro_THS_SOURCE”, the sodium silicate was investigated in the streptomycin dependent strains Escherichia coli B/Sd-4/1,3,4,5 and B/Sd-4/3. No evidence of mutagenicity was observed at concentrations of 0.025 - 0.3 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
