2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: QSAR

Test material

Test material information

Constituent 1

Reference substance name:

3,7,11,15-tetramethylhexadec-2-en-1-ol

EC Number:

616-221-6

Cas Number:

7541-49-3

Molecular formula:

C20H40O

IUPAC Name:

3,7,11,15-tetramethylhexadec-2-en-1-ol

Results and discussion

Remarks on result:

no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion

Conclusions:

In summary, we applied two Ames Test prediction models, ACD/TOX Ames Test and DS/TOPKAT Ames test QSTR model, for predicting the Ames test result of the compound 3,7,11,15-tetramethylhexadec-2-en-1-ol. Both prediction models suggested that the compound would have a positive Ames test result in a very low possibility. Based on model predictions in combination with the literature-reported Ames test result of similar compound Citronellol, it was predicted that the compound would have a negative result in bacterial reverse mutation test (Ames Test ) in a high possibility.