di-, tri- and tetrachlorotetradecane

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

End points of target substance di-, tri-, tetra- chlorotetradecane can be read across from source substance Alkanes, C14-17, chloro EC number: 287-477-0 | CAS number: 85535-85-9. This due to the following comparison:
1) di-, tri-, tetra- chlorotetradecane components make up the C14 content found in Alkanes, C14-17, chloro. It is therefore logical that di-, tri-, tetra- chlorotetradecane has been tested as a component of the larger group Alkanes, C14-17, chloro EC number: 287-477-0
2) The target and read-across molecules are both straight chain and therefore it is considered there are no major difference in steric hindrance between the substances (due to branched chain structures)
3) The functional groups are consistent between the target and read across substances, both are predominantly chlorinated alkanes

The degree of chlorination can affect the (eco)toxicology and physicochemical properties of the substance. The Substance Evaluation Conclusion Document for Medium-chain chlorinated paraffins /
alkanes, C14-17, chloro, EC No 287-477-0, CAS No 85535-85-9 conducted by evaluating members state United Kingdom (2019) https://echa.europa.eu/documents/10162/a72b228a-e417-5b53-b2b9-3b45c8e6eec5 includes direct comparisons of chlorinated alkanes with varying carbon chain lengths and chlorination for physical chemical tests and biodegradability screening tests. Examples include trend in Log Kow increasing with carbon chain length and vapour pressure decreasing with increased chlorination. A trend in biodegradation studies was also noted, increased chain length and chlorination severely disrupted the biodegradation processes.

To increase the accuracy of the read across, studies used from the Alkanes, C14-17, chloro REACH dossier will only include studies that used C14 components and similar levels of chlorination to di-, tri-, tetra- chlorotetradecane – 35 to 52 % chlorination.

For the above reasons the required endpoint is sufficiently covered by the testing on the read across substance Alkanes, C14-17, chloro EC number: 287-477-0 and the hazard adequately assessed. It is therefore considered that further testing is not required.

Reason / purpose for cross-reference:

read-across source

Key result

Temp.:

20 °C

Vapour pressure:

> 0 - < 0 mm Hg

Conclusions:

The vapour pressure is noted as being between 0.000001 and 0.000002 mm Hg (0.00013 and 0.00027 Pa) at 20°C.

Executive summary:

No study has been reported for di-, tri-, tetra- chlorotetradecane, but data have been reported for the principal constituents of di-, tri-, tetra- chlorotetradecane that are found in the similar substance Alkanes, C14-17, chloro. However, as Alkanes, C14-17, chloro contains a broad range of chloro-alkanes, only reports using test material containing C14 chloro-alkanes and similar levels of chlorination (35 to 52 % chlorination) have been used for the purposes of read across.

Using read across, it can be concluded that the vapour pressured for di-, tri-, tetra- chlorotetradecane would between 0.000001 and 0.000002 mm Hg (0.00013 and 0.00027 Pa) at 20°C.

Description of key information

 The upper value of 2.7 x 10-4 Pa at 20oC for a C14 -17 chlorinated paraffin (52% chlorinated) has been selected as a representative value for di-, tri-, tetra- chlorotetradecane 
    
    
    
    

The upper value of 2.7 x 10-4 Pa at 20oC for a C14 -17 chlorinated paraffin (52% chlorinated) has been selected as a representative value fordi-, tri-, tetra- chlorotetradecane











 
      
  
  
  
  

The upper value of 2.7 x 10-4 Pa at 20oC for a C14 -17 chlorinated paraffin (52% chlorinated) has been selected as a representative value fordi-, tri-, tetra- chlorotetrad 








    




The upper value of 2.7 x 10 

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of C14-17 chlorinated paraffins (52% chlorination) has been noted to be between 1 x 10-6 and 2 x 10-6 mm Hg (1.3 x 10-4 and 2.7 x 10-4 Pa) at 20°C (Campbell and McConnell, 1980), and at elevated temperatures as 1.07 x 10-3 Pa at 45oC, 6 x 10-3 Pa at 60oC and 0.051 Pa at 80oC (BUA, 1992; EU, 2005). A C14-17 chlorinated paraffin (45% chlorination) has a vapour pressure of 2.27 x 10-3 Pa at 40oC and 0.16 Pa at 80oC (BUA, 1992; EU, 2005).

There is no experimental information available on the variation of vapour pressure with carbon chain length and chlorine content for C14 -17 chlorinated paraffins. A study by Drouillard et al. (1998) found that vapour pressure of a series of short-chain chlorinated paraffins (C10 to C13) decreased with both increasing carbon chain length and chlorine content and so the same trend can be assumed for C14 -17 chlorinated paraffins. As di-, tri-, tetra- chlorotetradecane is only made fro mthe lowest carbon cahin length in C14 - 17 chlorinated paraffin the upper value of 2.7 x 10-4 Pa at 20oC for a C14 -17 chlorinated paraffin (52% chlorinated) has been selected as a representative value for di-, tri-, tetra- chlorotetradecane.