(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}-3-(1H-tetrazol-1-yl)propan-2-ol

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2020-01-28 to 2020-03-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 20 °C

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 25 °C

Key result

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 50 °C

The vapour pressure was measured in the solid state of the test item in the temperature range of 30 °C to 90 °C. The measured vapour pressures were below the detection limit of 1 × 10Exp-5 hPa. After the measurement no mass loss was determined. The measured vapour pressures at the corresponding temperatures are shown in Table 1.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature [°C]	Vapour pressure [hPa]
30	< 1 x 10Exp-5
40	< 1 x 10Exp-5
50	< 1 x 10Exp-5
60	< 1 x 10Exp-5
70	< 1 x 10Exp-5
80	< 1 x 10Exp-5
90	< 1 x 10Exp-5
60	< 1 x 10Exp-5

Detection limit: 1 x 10Exp-5 hPa

Since the test did not yield vapour pressures sufficiently high to extrapolate to 20, 25 and 50 °C these values were estimated according to the Antoine equation. The detection limit (1 × 10Exp-5 hPa) at the highest measurement point (90 °C) was used for the calculation as all measured vapour pressures were below the detection limit. Calculated vapour pressures are listed in Table 2.

Table 2: Calculated vapour pressures at 20, 25 and 50 °C

T [°C]	p [hPa]	p [Pa]
20	< 5.2 x 10Exp-9	< 5.2 x 10Exp-7
25	< 1.0 x 10Exp-8	< 1.0 x 10Exp-6
50	< 2.0 x 10Exp-7	< 2.0 x 10Exp-5

Conclusions:

The calculated upper limit vapour pressures for the test item are:
20 °C: < 5.2 x 10Exp-7 Pa
25 °C: < 1.0 x 10Exp-6 Pa
50 °C: < 2.0 x 10Exp-5 Pa

Executive summary:

The vapour pressure of the test item was determined according to OECD guideline 104 by the effusion method. All measured vapour pressures were below the detection limit of the effusion method. Based on the value of the detection limit (1 × 10Exp-5 hPa) at the highest measurement point (90 °C) the following upper limit vapour pressure values for the test item were calculated:

20 °C: < 5.2 x 10Exp-7 Pa

25 °C: < 1.0 x 10Exp-6 Pa

50 °C: < 2.0 x 10Exp-5 Pa

Description of key information

The vapour pressure of the test item was determined according to OECD guideline 104 by the effusion method. All measured vapour pressures were below the detection limit of the effusion method. Based on the value of the detection limit (1 × 10Exp-5 hPa) at the highest measurement point (90 °C) the following upper limit vapour pressure values for the test item were calculated:

20 °C: < 5.2 x 10Exp-7 Pa

25 °C: < 1.0 x 10Exp-6 Pa

50 °C: < 2.0 x 10Exp-5 Pa