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Diss Factsheets
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EC number: 951-219-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report similar or equivalent to OECD 406. GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- The available Buehler test provides information on skin sensitisation potential by measuring challenge-induced dermal hypersensitivity reactions elicited in test animals compared with controls.
Test material
- Reference substance name:
- Gasoline
- EC Number:
- 289-220-8
- EC Name:
- Gasoline
- Cas Number:
- 86290-81-5
- Reference substance name:
- unleaded gasoline
- IUPAC Name:
- unleaded gasoline
- Reference substance name:
- PS-6
- IUPAC Name:
- PS-6
- Test material form:
- other: low viscosity liquid hydrocarbon
Constituent 1
Constituent 2
Constituent 3
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: mineral oil
- Concentration / amount:
- Induction dose: 0.5 ml, neat
Challenge dose: 0.5 ml, 1:2 dilution in mineral oil
Positive Control DNCB:
Induction/Challenge: 0.05% DNCB in ethanol
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: mineral oil
- Concentration / amount:
- Induction dose: 0.5 ml, neat
Challenge dose: 0.5 ml, 1:2 dilution in mineral oil
Positive Control DNCB:
Induction/Challenge: 0.05% DNCB in ethanol
- No. of animals per dose:
- 10 males for induction/challenge
- Details on study design:
- A. INDUCTION EXPOSURE
- No. of exposures: 10
- Exposure period: 6 hours
- Frequency of applications: three times per week
- Duration: 3 weeks
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: Day 14 post-induction application
- Exposure period: 6 hours
- Evaluation (hr after challenge): 24 and 48 hr
OTHER: response grade score = erythema + edema - Challenge controls:
- Naive guinea pigs receiving only the challenge dose in order to distinguish between “background” irritation response and actual allergenic response.
Results and discussion
- Positive control results:
- Most of the positive control group animals showed evidence of sensitization.
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Group:
- test chemical
- Remarks on result:
- no indication of skin sensitisation
- Group:
- positive control
- Remarks on result:
- positive indication of skin sensitisation
- Group:
- negative control
- Remarks on result:
- other: Negative control scores not specified
Any other information on results incl. tables
Since the challenge treatment did not produce scores higher than the sensitizing treatment, the test substance was considered to be non-sensitizing.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Unleaded motor gasoline (API PS-6) did not induce a sensitisation response in guinea pigs in this study. This finding does not warrant the classification of the test article as a skin sensitiser under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
- Executive summary:
Male Hartley Albino guinea pigs were dermally exposed to unleaded motor gasoline (API PS-6), neat, at a volume of 0.5 ml for each of the three induction phases. For the challenge phase, unleaded motor gasoline was administered as a 1:2 dilution in mineral oil for the challenge and challenge control group animals. Response grades, severity and incidence at the time of the challenge exposure for the test article indicated no dermal responsiveness in the induction/challenge group above that observed in the naive challenge control group.
For the positive control group, response grades, severity and incidence at the time of the challenge exposure for DNCB resulted in a significantly higher response in the induction/challenge group than that observed in the naive challenge control group.
This finding does not warrant the classification of unleaded motor gasoline (API PS-6) as a skin sensitiser under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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