Registration Dossier
Registration Dossier
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EC number: 951-169-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: the case report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Methaemoglobinaemia after ingestion of amyl nitrite
- Author:
- R. J. Forsyth, A. Moulden
- Year:
- 1 990
- Bibliographic source:
- Arch Dis Child
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- Whether inhaled or swallowed, nitrites can produce anoxic states.
The administration of nitrites by any route can produce profound
methemoglobinemia. Tissue anoxemia can result from
methemoglobinemia (Darling and Roughton 1942; Lester andGreenburg 1944). Severe methemoglobinemia can result from
deliberate inhalation of room odorizer products (Home et al. 1979;
Shesser et al. 1981; Guss et al. 1985). Ingestion can produce a more
rapid and malignant methemoglobinemia than can inhalation and can
be lethal (Dixon et al. 1981; Shesser et al. 1980; Shesser et al. 1981;
Smith et al. 1980; Wason et al. 1980) In addition, the alkyl nitrites are metabolized to nitrite ions and the corresponding alcohol, which may lead to delayed deaths or hepatotoxicity Intraperitoneal -Amyl- LD50 - Mouse 130 mg/kg Dewey et al. 1973 (111-152)
Intravenous - Amyl – LD50 - Mouse 51 mg/kg Dewey et al. 1973 (38-68) (24-hours LD50)
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
- EC Number:
- 951-169-0
- Molecular formula:
- C15H46N2O10
- IUPAC Name:
- 2-methylbutan-1-ol; 2-methylbutyl nitrite; pentan-1-ol; pentyl nitrite
- Test material form:
- liquid
Constituent 1
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Remarks on result:
- other: not specified
Any other information on results incl. tables
Acute Tox 4; H302
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
