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EC number: 236-770-1 | CAS number: 13477-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (similar to OECD 401): LD50>5000 mg/kg bw (BASF 1983; 83/186)
Acute inhalation toxicity (IHT): No mortality after 7h exposure of a vapor saturated atmosphere (BASF1993;10I0358/927012).
Acute dermal toxicity (similar to OECD 402): LD50>2000 mg/kg bw (BASF 1984; 83/186)
Key value for chemical safety assessment
Additional information
Acute oral toxicity
In the chosen key study for acute oral toxicity, i.e. an internal acute toxicity test similar to OECD 401, 5 Wistar rats per sex were treated via a single oral dose (gavage) with 2150, 3160 and 5000 mg/kg tetrahydro-2-isobutyl-4-methyl-2H-pyran (BASF 1983; 83/186). Test substance related mortality has been observed in 1/10 animals at 5000 mg/kg bw only. The LD50 has been reported to be >5000 mg/kg bw. Therefore tetrahydro-2-isobutyl-4-methyl-2H-pyran was found to be virtually non-toxic after single oral administration.
Acute inhalation toxicity
No key study is available for acite inhalation toxicity of . In a supportive study, i.e. an inhalation hazard test, 3 Wistar rats per sex were exposed (whole body) to a vapor saturated atmosphere with a nominal concentration of 23.1 mg/l tetrahydro-2-isobutyl-4-methyl-2H-pyran (not verified analytically) for 7 hours (BASF1993;10I0358/927012). No mortality was observed and eyelid closure and accelerated respiration at the beginning of exposure were the only clinical signs detected. Therefore, the inhalation of a highly saturated vapor-air mixture of tetrahydro-2-isobutyl-4-methyl-2H-pyran represents no acute hazard.
For the coverage of a second and human relevant route of exposure, a study on acute dermal toxicity is available (see below). Overall, an acute toxicity study via the inhalative route is scientifically not required and would not be in line with animal welfare requirements.
Acute dermal toxicity
In the chosen key study for acute dermal toxicity, i.e. an internal acute toxicity test similar to OECD 402, 5 Wistar rats per sex were treated via a single dermal (semiocclusive) application of undiluted tetrahydro-2-isobutyl-4-methyl-2H-pyran (2000 mg/kg) for 4 hours (BASF 1984; 83/186). No test substance related mortality has been observed. The LD50 has been reported to be >2000 mg/kg bw. Therefore tetrahydro-2-isobutyl-4-methyl-2H-pyran was found to be virtually non-toxic after single dermal administration.
Justification for classification or non-classification
The present data on acute oral and dermal toxicity do not fulfill the criteria laid down in regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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