Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The 48-hr EC50 for daphnia magna was > 100 mg/L, based on nominal values, and > 5.30 mg/L, based on tungsten (W) determinations. The results do not meet the CLP classification for aquatic toxicity. This conclusion is based on the nominal loading rate of the test item (100 mg/L) reported in the study. According to Annex IV of ECHA's CLP guidance version 5.0, it is the loading level which yields the level of metal ion equivalent to the available LC50 or NOEC/EC10 that can then be used to determine the acute or long-term hazard category appropriate for classification. For this daphnia study, the 48-hr EC50 reported was >100 mg/L (nominal) which is greater than the CLP cut-off limit (100 mg/L) for both the acute and chronic aquatic hazard classifications.
The 72-hr EC50 for algae growth rate inhibition, based on the nominal values, was 137.25 mg/L. The 72-hr EC50 for algae growth rate inhibition, based on the Cs-determination, was 21.58 mg/L. The 72-hr EC50 for algae growth rate inhibition, based on the W-determination, was 5.37 mg/L.
The 72-hr EC10 for algae growth rate inhibition, based on the nominal values, was 31.60 mg/L. The 72-hr EC10 for algae growth rate inhibition, based on the Cs-determination, was 4.97 mg/L. The 72-hr EC10 for algae growth rate inhibition, based on the W-determination, was 1.27 mg/L.
These results do not meet the CLP classification for aquatic toxicity. This conclusion is based on the nominal loading rate of the test item (137.25 mg/L) reported in the study. According to Annex IV of ECHA's CLP guidance version 5.0, it is the loading level which yields the level of metal ion equivalent to the available EC50 or NOEC/EC10 that can then be used to determine the acute or long-term hazard category appropriate for classification. For this algae study, the 72-hr EC50 (growth rate inhibition) reported was >100 mg/L (nominal) which is greater than the CLP cut-off limit (100 mg/L) for both the acute and chronic aquatic hazard classifications.
Additional information
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