Registration Dossier
Registration Dossier
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EC number: 421-640-0 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-04-24 - 1996-08-15 (experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- The experimental procedure used complied with that specified in Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.2
- Remarks on result:
- other: no further information available
- Details on results:
- Due to the low solubility of the test material in both water and n-octanol it was not possible to make a preliminary estimate of the partition coefficient.
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item, determined in a GLP study according to EU Method A.8., was determined to be log Pow ≥ 6.2.
- Executive summary:
The determination of the partition coefficient log Pow of Polyperin Y was performed using the HPLC method as described in EEC Directive 92/69, Section A.8.
The partition coefficient of the test item has been determined to be greater than 1.59 x 106, Log10 Pow ≥ 6.2, for 94% of the test material (by normalisation HPLC). Under the conditions of the test, the reference standards did not show any significant retention on the HPLC column. The log10 Koc of the sample was deduced by direct comparison of the sample retention times with that of the standard having the highest log10 Koc value. Substances having a Log10 Pow greater than 3 are regarded as having the potential to bioaccumulate in the environment.
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