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EC number: 406-670-4 | CAS number: 61203-83-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1990 - January 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken immediately after the start of the test and after 2h, 4h and 5 days.
- Buffers:
- - pH: 4: 50 mL monopotassium phosphate solution (0.1 mol/L) at 50°C pH adjusted to 4,0 with HCl (0.1 mol/L), diluted with water to 100 mL
- pH: 7: 50 mL monopotassium phosphate solution (0.1 mol/L) at 50°C pH adjusted to 7,0 with NaOH (0.1 mol/L), diluted with water to 100 mL
- pH: 9: 50 mL Boric acid solution (0.1 mol/L in KCl (0.1 mol/L)) at 50°C pH adjusted to 9,0 with NaOH (0.1 mol/L), diluted with water to 100 mL - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: Iodine determination flask, brown glass, 100 mL
- Measures to exclude oxygen: flasks aerated with nitrogen gas
- Is the test system closed/open: closed system
- Is there any indication of the test material adsorbing to the walls of the test apparatus? No
TEST MEDIUM
- Volume used/treatment: 50 mL
- Renewal of test solution: no - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 30 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 30 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 30 mg/L
- Number of replicates:
- 3
- Positive controls:
- yes
- Remarks:
- acetylsalicylic acid
- Negative controls:
- not specified
- Statistical methods:
- Mean values and standard deviation were calculated with a programmed pocket calculator (TI SR-51-11).
- Test performance:
- The hydrolysis of the substance was below 50% independent of the pH. The differences between the hydrolysis after 2-4h and 5 days were for all pH values in the range of the standard deviation.
- Transformation products:
- not measured
- % Recovery:
- 78.4
- St. dev.:
- 5.3
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 83
- St. dev.:
- 4.16
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- >= 2 - <= 4 h
- % Recovery:
- 91.73
- St. dev.:
- 2.37
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 90.97
- St. dev.:
- 2
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- >= 2 - <= 4 h
- % Recovery:
- 102.13
- St. dev.:
- 5.49
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 94.3
- St. dev.:
- 12.44
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- >= 2 - <= 4 h
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
The test substance is an arylketone, theoretical no hydrolisation is possible. As the decrease in concentration is almost stable between 4h and 5 days, an artifact of the method could be responsible. As the water solubility of the substance is not good, the determination of the concentration is only possible with a relatively large error. The results lead to a DT50 of the test substance in the environment of more than one year. - Results with reference substance:
- The reference substance acetylsalicylic acid is totally hydrolysed after 5 days independent of the pH value. After 2-4h at pH 4 72.73 % of the start concentration were measured, at pH 7 50.93% and at pH 9 45.60%.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrolysis of the test substance was determined according to OECD 111. Under the given conditions the DT50 is more than one year.
- Executive summary:
The hydrolysis of the test substance was determined according to OECD 111. The test substance (30 mg/L) and 50 mL of the buffer solution (pH 4, 7 and 9) were put in brown iodine determination flasks. The three replicates were analysed with GC after 2h, 4h and 5 days. Additionally the hydrolysis of the reference substance acetylsalicylic acid was determined the same way and analysed with HPLC. Mean values and standard deviation were calculated with a programmed pocket calculator (TI SR-51-11). The hydrolysis of the test substance was below 50% independent of the pH. The differences between the hydrolysis after 2-4h and 5 days were for all pH values in the range of the standard deviation. The reference substance acetylsalicylic acid is totally hydrolysed after 5 days independent of the pH value. After 2-4h at pH 4 72.73 % of the start concentration were measured, at pH 7 50.93% and at pH 9 45.60%. The test substance is an arylketone, theoretical no hydrolisation is possible. As the decrease in concentration is almost stable between 4h and 5 days, an artifact of the method could be responsible. As the water solubility of the substance is not good, the determination of the concentration is only possible with a relatively large error. The results lead to a DT50 of the test substance in the environment of more than one year.
Reference
Description of key information
The hydrolysis of the test substance was determined according to OECD 111. Under the given conditions the DT50 is more than one year (reference 5.1.2 -1).
Key value for chemical safety assessment
Additional information
The hydrolysis of the test substance was determined according to OECD 111. The test substance (30 mg/L) and 50 mL of the buffer solution (pH 4, 7 and 9) were put in brown iodine determination flasks. The three replicates were analysed with GC after 2h, 4h and 5 days. Additionally the hydrolysis of the reference substance acetylsalicylic acid was determined the same way and analysed with HPLC. Mean values and standard deviation were calculated with a programmed pocket calculator (TI SR-51-11). The hydrolysis of the test substance was below 50% independent of the pH. The differences between the hydrolysis after 2-4h and 5 days were for all pH values in the range of the standard deviation. The reference substance acetylsalicylic acid is totally hydrolysed after 5 days independent of the pH value. After 2-4h at pH 4 72.73 % of the start concentration were measured, at pH 7 50.93% and at pH 9 45.60%. The test substance is an arylketone, theoretical no hydrolisation is possible. As the decrease in concentration is almost stable between 4h and 5 days, an artifact of the method could be responsible. As the water solubility of the substance is not good, the determination of the concentration is only possible with a relatively large error. The results lead to a DT50 of the test substance in the environment of more than one year (reference 5.1.2 -1).
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