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EC number: 222-001-7 | CAS number: 3312-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no statistics provided
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-cyclohexylaminopropylamine
- EC Number:
- 222-001-7
- EC Name:
- 3-cyclohexylaminopropylamine
- Cas Number:
- 3312-60-5
- Molecular formula:
- C9H20N2
- IUPAC Name:
- N1-cyclohexylpropane-1,3-diamine
- Test material form:
- liquid
- Details on test material:
- 3-Cyclohexylaminopropylamine from Performance Chemicals, lot number: 68-219-BC
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- weight range of rats was 170 to 260 grams
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats were fasted overnight, then given single oral dose of compound by stomach tube. The compound was given undiluted or as a 1:10 dilution in water.
After dosing, each rat was returned to its cage and provided with water and food. - Doses:
- 100, 215, 464, 1000, 2150 mg/kg
- No. of animals per sex per dose:
- 5 per sex and dose
- Control animals:
- no
- Details on study design:
- After dosing, each rat was returned to its cage and provided with water and food. Close observations for signs of toxicity was maintained on each animal the next one or two hours, and at intervals the rest of the working day. Daily checks were made thereafter for seven days at which the general condition of the rats was evaluated and any deaths recorded.
Survivors at seven days were sacrifieced and gross autopsies performed on representatives remaining from the higher doses. Some animals dying during the first day were also autopsied. - Statistics:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 200 - <= 237 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 142 - <= 395 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 137 - <= 291 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality increased in lower dose groups from day 2 to 7 and in higher dose groups (from 464 mg/kg) from 1h to 2 days (see table)
- Clinical signs:
- other: Excessive salivation, depression, tremors, lacrimation, labored breathing, bloody urine, convulsions
- Gross pathology:
- At lethal doses extensive gastrointestinal hemorrhaging, urinary bladder hemorrhage.
At non lethal doses: Irritation to gastrointestinal tract, enlarged spleen, discolored kidneys and liver
Any other information on results incl. tables
Mortality by days | |||||||||
Dose in mg/kg | sex | 1 hour | 1 day | 2 days | 3 days | 4 days | 5 days | 6 days | 7 days |
2150 | m | 5/5 | |||||||
f | 5/5 | ||||||||
1000 | m | 5/5 | |||||||
f | 5/5 | ||||||||
464 | m | 4/5 | 4/5 | 5/5 | |||||
f | 5/5 | ||||||||
215 | m | 1/5 | 1/5 | ||||||
f | 2/5 | 2/5 | |||||||
100 | m | 1/5 | 1/5 | ||||||
f | 0/5 |
Applicant's summary and conclusion
- Conclusions:
- Based on the test results of the acute oral toxicity study in rats, the LD50 is estimated to be between 200 - 237 mg/kg.
- Executive summary:
The acute oral toxicity of the test compound was determined in groups of albino rats consisting of five males and five females. The test material was administrated by gavage once and the animals were observed for seven days. The tested dose concentrations were 100, 215, 464, 100 and 2150 mg/kg. Based on the test results of the acute oral toxicity study in rats, the LD50 is estimated to be between 200 - 237 mg/kg.
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