Registration Dossier
Registration Dossier
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EC number: 217-100-7 | CAS number: 1739-83-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,2,4,5-tetramethyl-1H-imidazole
- EC Number:
- 217-100-7
- EC Name:
- 1,2,4,5-tetramethyl-1H-imidazole
- Cas Number:
- 1739-83-9
- Molecular formula:
- C7H12N2
- IUPAC Name:
- tetramethyl-1H-imidazole
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- <= 1 mg/L
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- >= 3.2 mg/L
- Details on results:
- The 72-hours EyC50 value for algae Pseudokirchneriella subcapitata exposed to 1,2,4,5-tetramethyl-1H-imidazole was 7.19 mg.L-1 and the 72-hours ErC50 value was not identified because the highest concentration tested 100 mg.L-1 caused only 35% inhibition of growth rate. The highest test item concentration with no observed significant adverse effect (NOEC) on algal growth was 1 mg.L-1 and the lowest test item concentration at which was observed significant reducing effect on growth (LOEC) was 3.2 mg.L-1.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 72-hours EyC50=7.19 mg.L-1
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