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Diss Factsheets
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EC number: 473-370-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 October 2007 to 28 November 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: at 100 and 220 mg/L at t=0 and t=48 h
- Sampling method: 1.5 mL from the approximate centre of the vessels
- Sample storage conditions before analysis: freezing - Vehicle:
- yes
- Remarks:
- water
- Details on test solutions:
- solutions were ultrasonicated for 10 minutes followed by magnetic stirring during maximum 20 minutes. The solutions were clear and colorless. The lower test concentrations were dilutions of the highest concentration.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Straiss 1820
- Age at study initiation: < 24 h
- Stage and instar at study initiation: 2nd to 5th brood of parents of less than 2 weeks old
- Method of breeding: acyclic parthenogenesis
- Source: in-house culture
- Feeding during test : none
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 160 mg/L as CaCO3
- Test temperature:
- 18.9-19.6 ˚C (measured in control vessel)
- pH:
- 7.7-7.9
- Dissolved oxygen:
- 9.2-9.4 mg/L
- Nominal and measured concentrations:
- Nominal: 10, 22, 46, 100 and 220 mg/L
Measured concentrations (at 100 and 220 mg/L) were between 100 and 104% of nominal - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL all glass containing 80 mL test solution
- Type: open
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: adjusted ISO medium
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 hours light
EFFECT PARAMETERS MEASURED: immobility at 14 and 48 hours
RANGE-FINDING STUDY
- Test concentrations: 0.1,1.0,10 and 100 mg/L (5 daphnids/ vessel, 2 vessels/concentration for the lower concentrations and 4 at 100 mg/L)
- Results used to determine the conditions for the definitive study: immobility of 0, 0, 0 and 65% at 0.1,1.0,10 and 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- 6 concentrations of potassium dichromate between 0.10 and 1.8 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 220 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- immobility was 0, 0, 0, 0, 5 and 10% at control, 10, 22, 46, 100 and 220 mg/L
- Results with reference substance (positive control):
- 48-h EC50 for potassium dichromate: 0.42 mg/L
- Reported statistics and error estimates:
- NA
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-h EC50 for the substance is > 220 mg/L
- Executive summary:
In a static test according to OECD 202, 20 daphnids per concentration (5/vessel) were exposed during 48 hours to the substance at concentrations of 10, 22, 46, 100 and 220 mg/L. After 48 hours immobility was 0, 0, 0, 0, 5 and 10% in control, 10, 22, 46, 100 and 220 mg/L. The EC50 is > 220 mg/L.
Reference
Description of key information
In a static test according to OECD 202, 20 daphnids per concentration (5/vessel) were exposed during 48 hours to the substance at concentrations of 10, 22, 46, 100 and 220 mg/L. After 48 hours immobility was 0, 0, 0, 0, 5 and 10% in control, 10, 22, 46, 100 and 220 mg/L. The EC50 is > 220 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 220 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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