Registration Dossier
Registration Dossier
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EC number: 202-987-5 | CAS number: 101-90-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- The study was published in 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 958
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The material was tested on normal rabbit eyes as a 20% suspension in propylene glycol. Observations were made 1, 24 and 48 h after application and any injury scored according to the method of Draize (1955)
- GLP compliance:
- no
Test material
- Reference substance name:
- m-bis(2,3-epoxypropoxy)benzene
- EC Number:
- 202-987-5
- EC Name:
- m-bis(2,3-epoxypropoxy)benzene
- Cas Number:
- 101-90-6
- Molecular formula:
- C12H14O4
- IUPAC Name:
- 2-({3-[(oxiran-2-yl)methoxy]phenoxy}methyl)oxirane
- Test material form:
- liquid: viscous
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- Albino
- Details on test animals or tissues and environmental conditions:
- - Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Body weights were 2.0 - 3.2 kg
- Housing: Not reported
- Diet: Not reported
- Water: Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS: Not reported
Test system
- Vehicle:
- other: Propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: 0.1 mL of a 20% suspension in propylene glycol
- Duration of treatment / exposure:
- Single instillation on Day 1
- Observation period (in vivo):
- 48 h
- Number of animals or in vitro replicates:
- not specified
- Details on study design:
- STUDY DESIGN
The test material was applied as a 20% suspension in propylene glycol on the center of the cornea
REMOVAL OF TEST SUBSTANCE
-Washing: No
OBSERVATIONS
- Irritation: Readings were made at 1, 24 and 48 hours, with the corneas unstained and then stained with a 2% solution of fluorescein sodium. Injury was scored according to the method of Draize (1955)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- according to the method of Draize (1955)
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 45
- Max. score:
- 120
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Remarks:
- Severely irritating
Applicant's summary and conclusion
- Interpretation of results:
- other: Eye irritation scores ahoed Diglycidyl resorcinol to be severely irritating
- Conclusions:
- In an eye irritation study with rabbits, the eye irritation scores showed Diglycidyl resorcinol to be severely irritating
- Executive summary:
The substance was tested in an eye irritation test in rabbits. The results showed that the substance is a severe ocular irritant.
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