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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
- Molecular formula:
- C32H16N8Co(SO3)n with n=0 to 3
- IUPAC Name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rabbits were individually identified by means of numbered ear tags. The rabbits were acclimated to the laboratory for 27 days before dosing.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- The dose was applied to the abdominal skin area from which the fur had been previously removed with electric clippers. The abdominal skin area of all of the rabbits iri each group was abraded by making a series of longitudinal minor epidermal incisions placed two to three centimeters apart, using a hypodermic needle as a cutting tool. The abrasions were sufficiently deep to penetrate the epidermis, but not to induce bleeding. The undiluted sample was moistened with 4 milliliters of physiological saline and applied at a dosage level of 2.0 g/kg of body weight. The test sample was kept in contact with the skin on at least 1056 of the body surface. The sample was placed in a sleeve of rubber dental damming in which a pocket had been formed to furnish a reservoir for the dose. The dental damming was wrapped around the trunk of the animal and secured with staples. An outer layer of gauze was placed around the trunk of the animal. The rabbit was restrained for approximately 23 1/2 to 23 3/4 hours in a Newmann harness.
- Duration of exposure:
- 24h
- Doses:
- 2g/ kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- During the exposure each rabbit was observed for signs of toxicity at approximatelyone, two, four, and twenty-one hours post-application. The observation at 21 hours was not prescribed in the protocol.
At the end of the exposure period the binder was removed and any unabsorbed sample remaining on the s^in was removed by gentle sponging with a moistened towel. Each rabbit was examined thoroughly for gross signs of systemic toxicity and dermal irritation.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities occurred during the course of the study.
- Clinical signs:
- other: Erythema and edema, followed by desquamation and sometimes atonia were seen at the application site in each animal. Most effects ranged from mild to marked in severity. Scar tissue was observed in eight animals during the second week of observations.
- Gross pathology:
- Gross necropsies performed upon the termination of the study revealed two rabbits (Nos. 3 and 8) with pitted kidneys. Gas in the intestine of two rabbits (Nos. 3 and 7) was also noted. These findings were not considered drug-related. No other gross changes were found.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD value of Cobalt Phthalocyanine Sulfonate was found to be greater than 2.0 g/Kg of body weight for New Zealand White rabbits.
Irritative effects noted during the study included desquamation, atonia, erythema, spotted whitening, edema, and scar tissue on abrasions. No systemic effects were found. None of the animals died.
Under tests conditions, test item do not required classification according to GHS criteria.
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