Indene

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 02 August 2018 to 17 August 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Indene

EC Number:

202-393-6

EC Name:

Indene

Cas Number:

95-13-6

Molecular formula:

C9H8

IUPAC Name:

indene

Test material form:

liquid

Details on test material:

Appereance: Colorless transparent liquid
Storage conditions: At room temperature container flushed with nitrogen

Results and discussion

Water solubility

Key result

Water solubility:

0.171 g/L

Incubation duration:

>= 48 - <= 72 h

Temp.:

20 °C

pH:

>= 7.5 - <= 7.8

Any other information on results incl. tables

Table: water solubility results (flask method)

Stirring time [hours]	Analyzed concentration [g/L]	Mean [g/L]	Maximum difference [%]	pH
24	0.169			6.9
24	0.147			7.2
24	0.151			7.2
48	0.177			7.8
48	0.170			7.7
48	0.166	0.171*	13*	7.5
72	0.182			7.5
72	0.169			7.8
72	0.161			7.6

*An unacceptable maximum difference of > 15% would be obtained when taken all results into account due to the low concentrations analysed in most of the samples taken after 24 hours of stirring. The water solubility was therefore calculated as the mean value of the 48- and 72-hour measurements (maximum difference < 15%).

No test item was detected in the pretreated sample from the blank.

Applicant's summary and conclusion

Conclusions:

The water solubility of the substance at 20°C was determined to be 0.171 g/L.

Executive summary:

The water solubility of the substance was determined using the flask method in a GLP study based on EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-UV. The pH of the aqueous samples was 7 -8. As saturation equilibrium was not yet reached after 24 hours of stirring, the water solubility was calculated from the measurements obtained after 48 and 72 hours of stirring to be 0.171 g/L.