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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
long-term toxicity to fish, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
please see attached backgroud materials:QPRF and QMRF

Data source

Reference
Reference Type:
other: QSAR report
Title:
Improved method for estimating long-term toxicity to fish
Year:
2018
Bibliographic source:
Environ. Toxicol. Chem. 15: 100-106.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSAR R.6 may/july 2008
Principles of method if other than guideline:
REACH guidance on QSAR R.6 may/july 2008
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
D-mannitol
EC Number:
200-711-8
EC Name:
D-mannitol
Cas Number:
69-65-8
Molecular formula:
C6H14O6
IUPAC Name:
D-mannitol
Test material form:
solid: crystalline

Results and discussion

Effect concentrations
Key result
Duration:
14 d
Dose descriptor:
other: ChV
Effect conc.:
> 10 000 mg/L

Applicant's summary and conclusion