Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-465-2 | CAS number: 8047-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, pre-GLP, doses not specified
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- N-ethyl-o(or p)-toluenesulphonamide
- EC Number:
- 232-465-2
- EC Name:
- N-ethyl-o(or p)-toluenesulphonamide
- Cas Number:
- 8047-99-2
- Molecular formula:
- C9H13NO2S
- IUPAC Name:
- N-ethyl-4-methylbenzene-1-sulfonamide
- Test material form:
- liquid: viscous
- Remarks:
- Colour: light yellow
- Details on test material:
- Ketjenflex 8 (NETSA)
Chemical name in report: N-ethyl-o/p-toluenesulfonamide (or N-substituted toluene sulphonamide)
Description: light yellow viscous liquid
Purity 100% (or 90%)
Test substance storage: at room temperature in the dark
Stability under storage conditions: stable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- Animals were exposed for 3 consecutive days of 8 hours.
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- other: saturated vapours at 177 deg C.
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None
- Clinical signs:
- other: Moderate discomfort, slight nasal discharge, inflammation, letargy.
Any other information on results incl. tables
No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- according to the EU classification criteria outlined in Annex I of 1272/2008/EC (CLP)
- Conclusions:
- No deaths occured in a 3 consecutive day 8 hours exposure of air saturated by Santicizer 8 vapours at 177 deg C .
- Executive summary:
Four mature male rats (Sprague-Dawley) were placed in a metal chamber of approximately 35 liters for three consecutive eight hour days to a saturated atmosphere of Sanitizer 8 vapours produced by heating the liquid to 350 deg F (177 deg C). 250 mL of sample was placed in a three hals round bottom flask and the vapours were led into the chamber through a short lenght of hose. A gas burner was used to maintain the proper temperature. Food and water were applied ad lib. Observations were done for behaviour and since there were no deaths, all animals were held for seven days following the test. The average temperature inside the chamber was 76.0 deg F and the average humidity was 58.0%.
No deaths resulted from the three days exposure. Whitish, aury vapours were given off at a sufficient rate to maintain a moderate inside the chamber. In all probability the atmosfere was kept saturated. Mild discomfort was noted within a few minutes after the start of each days exposure. This developed into moderate lethargy with mild to moderate inflammation of the nasal route. Breating remained about normal. There was moisteming of the nasal passages but only slight discharge. The animals looked normal at the start of each days test and no compications developed during a seven day holding period. The compound becomes dark in colour in one to two hours after being heated. It was comcluded that Santicizer 8 vapours given off at 350 deg F.are moderately irritating in a saturated atmoshere. They were not acutely toxic to rats.
As a result, the substance N-Ethyl-o (or p)-toluenesulfonamide (NETSA) does not need to be classified for acute inhalation toxicity according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.