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Diss Factsheets
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EC number: 236-942-6 | CAS number: 13557-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details and justification of read-across please refer to the report attached in section 13 of IUCLID.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.439 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No effects on behaviour or survival of fish were detected during the test course up to and including the highest test concentration of 0.439 mg/L.
- Reported statistics and error estimates:
- Not applicable
- Sublethal observations / clinical signs:
Neither biological effects nor mortality occurred during the test.
Validity criteria according the OECD guideline 203 were met:
• Mortality did not exceed 10 % in the controls.
• The dissolved oxygen concentration was ≥ 60 % in test vessels throughout the test.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 was determined to be > 0.439 mg/L Sodium-Isostearoyl-Lactylate (geometric mean measured).
- Executive summary:
In a 96-h acute toxicity study, zebra fish (Danio rerio) were exposed to Sodium-Isostearoyl-Lactylate at nominal concentrations of 0.0 (control) and 6.25, 12.5, 25.0, 50.0 and 100.0 mg/L under semi-static conditions. The LC50 value, based on mortality, was > 0.439 mg/L (geometric mean measured concentration). Sublethal effects were not observed.
Based on the results of this study, the test item would be not classified as toxic to zebra fish in accordance with the CLP classification system.
This toxicity study is classified as acceptable and satisfies the guideline requirement for the zebra fish acute toxicity study.
Results synopsis
Test organism size/age: Danio rerio (size 2.0 cm ± 1.0 cm)
Test type: Semi-static
LC50 > 0.439 mg/L
Endpoint(s) effected: Mortality, other effects (i.e. swimming behaviour, colour, respiratory function or any other observable morphological or visual behavioural criterion)
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Reference
Description of key information
To evaluate the toxicity of sodium lauroyl lactylate (SLL) to fish read-across from sodium isostearoyl lactylate (ISL) is available.
In a valid 96-h acute toxicity study, zebra fish (Danio rerio) were exposed to sodium isostearoyl lactylate at nominal concentrations of 0.0 (control) and 6.25, 12.5, 25.0, 50.0 and 100.0 mg test item/L under semi-static conditions. The LC50 value, based on mortality and sublethal effects, was > 0.439 mg/L (geometric mean measured concentration). This was the maximum attainable test substance concentration. Neither mortality nor any sublethal effects were observed.
The absence of any mortality indicates that, according to the threshold approach for acute fish toxicity, fish is not the most sensitive group of test organisms after short-term exposure to sodium isostearoyl lactylate.
This information is used in a read-across approach in the assessment of the target substance sodium lauroyl lactylate (SLL).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.