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EC number: 418-400-2 | CAS number: 1031-15-8 METHYL-TPP-CHLORID; MTPP-CHLORID
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 27 - March 25, 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Feb 24, 1987
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyltriphenylphosphonium chloride
- EC Number:
- 418-400-2
- EC Name:
- Methyltriphenylphosphonium chloride
- Cas Number:
- 1031-15-8
- Molecular formula:
- C19H18ClP
- IUPAC Name:
- methyltriphenylphosphanium chloride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Source:
Kaninchenhof Süstedt, Alter Pohl 8, 27305 Süstedt
Animal selection:
random
Animal identification:
with individual ear tags; cage labelled with ear tag no., sex, date of study initiation, project no.
Housing:
individual housing (50 x 45 x 40 cm, L x B x H) in a battery of cages, each equipped with a paper roll disposal system
Illumination:
artificial lighting (120 lux) from 7.00 a.m. -7.00 p.m.
Temperature:
20 +/- 3°C
Relative humidity:
30-70%
measurement:
twice daily
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 g of the test item
- Observation period (in vivo):
- Ocular reactions were assessed 1, 24, 48 and 72 h after treatment and thereafter once daily up to day 12 post applicationem. On each occasion, ocular irritation and/or corrosion were scored according to the scheme presented on the next two pages. At 48 h p.a., secretions had to be removed from the treated eye with warm saline to make an assessment possible.
- Number of animals or in vitro replicates:
- 1 animal
- Details on study design:
- 24 h before treatment, the eyes of the animal were examined for potential ocular lesions. Since the animal showed no evidence of ocular abnormalities it was used in the test.
The test article was administered in the original state.
0.1 g of the test article was introduced into the conjunctival sac of the left eye, while the right eye served as control. Because of the pain reaction of the animal immediately after the introduction of the test article, a local anaesthetic was used.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 12 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 12 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 12 days
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Immediately after administration the test article caused unreasonable pain in the animal, so that a local anaesthetic (Novesine@, Wander 1 %) was used. Moderate to severe redness and swelling of the conjunctiva were observed during the entire observation period. Hyperemia of the iris was seen 1 h p.a. and was still apparent up to day 9 p.a. On the following days, irritation of the iris could not be evaluated because
of the extreme corneal opacity. Moderate to extreme corneal opacity was observed from 1 h p.a. up to the end of the observation period. Additionally, there was a strong formation of milky secreta 48 and 72 h p.a..
The observed findings persisted and were not reversible until day 12 p.a. On this day the animal was sacrificed because of the severe findings and the incipient destruction of the eyeball. - Other effects:
- No other toxic effects were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test for acute eye irritation/corrosion according to OECD Guideline No. 405 was performed with the test item.
Under the conditions of the present study, a single ocular application of the test item to rabbit at a dose of 0.1 g produced severe effects. The observed findings were not reversible up to the killing for animal protection reasons at day 12 p.a.. - Executive summary:
The potential toxicity of the test item was assessed in an acute eye irritation/corrosion test on one albino rabbit. 0.1 g of the test article was introduced into the conjunctival sac of one eye, the untreated eye serving as control. Both eyes were examined at 1,24,48 and 72 h post applicationem and thereafter once daily up to day 12 post applicationem. For reasons of severe fmdings, the test was terminated on day, 12 p.a. and the animal was sacrificed.
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