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EC number: 832-253-5 | CAS number: 12165-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There is no experimental data available on skin sensitisation for the substance dipraseodymium dizirconium heptaoxide. However, using a weight of evidence approach including experimental data available for its constituents praseodymium(III,IV) oxide and zirconium dioxide (in the latter case, a zirconium dioxide test item was used in which a small amount of yttrium oxide was incorporated in the crystal lattice), it can be concluded that the substance is not expected to be a skin sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
1. Information on praseodymium(III,IV) oxide
In a study (Henzell, 2012; Klimisch 1) conducted to test the skin sensitisation properties of praseodymium(III,IV) oxide following OECD guideline 429 (LLNA), the results for all concentrations of the test material were negative. The positive control material yielded the expected result. Therefore, praseodymium(III,IV) oxide was considered to be a non-sensitiser under the conditions of this study in accordance with the CLP criteria.
2. Information on zirconium dioxide
Since no skin reaction was acknowledged in the elicited region of either the test agent group or the control group in the OECD 406 study (GPMT) performed by the Japanese Chemical Inspection and Testing Institute (1999; Klimisch 2 (non-GLP)), it was concluded that the test substance yttrium zirconium oxide (i.e. zirconium dioxide with a small amount of yttrium oxide incorporated into its crystal lattice) does not have any skin sensitising potential under the conditions of this test. On the other hand, it was confirmed that 2,4-dinitrochlorobenzene, the positive control agent, has an extreme skin sensitising potential. Since the result for the yttrium zirconium oxide test item was negative, it can be concluded that zirconium dioxide is also not a sensitiser.
3. Conclusion for the substance dipraseodymium dizirconium heptaoxide
Based on the negative results obtained for praseodymium(III,IV) oxide and zirconium dioxide (with a small amount of yttrium oxide incorporated into its crystal lattice) in skin sensitisation studies, it is safe to conclude that the substance dipraseodymium dizirconium heptaoxide does not need to be classified for skin sensitisation either.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance does not need to be classified as skin sensitiser. This conclusion is based on the negative results of experiments performed with praseodymium(III,IV) oxide and zirconium dioxide (with a small amount of yttrium oxide incorporated into its crystal lattice).
No information is available on respiratory sensitisation.
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