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EC number: 204-729-7 | CAS number: 125-20-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: information from boiling point determination via DSC
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
- Decomposition:
- yes
- Decomp. temp.:
- >= 240.8 °C
- Remarks on result:
- other: substance decomposes before melting
- Conclusions:
- The boiling point could not be determined under the test circumstances. In both DSC measurements two endothermic peaks were detected. Between those an exothermic behaviour was observed. The beginning of decomposition from 240.8 °C was evaluated with event marker function. The melting point was evaluated with onset function. Therefore, the melting point of the decomposition product was determined as: 253.46 ± 0.33°C (526.61 ± 0.33 K)
The study was performed according to the OECD TG109 and EU Method A.3 without deviations and therefore considered to be of the highest quality (reliability Klimisch 1). - Executive summary:
The boiling point of the test item was determined in a study according to OECD 103 resp. EU Method A.2 (DSC).
The test substance was filled into a sample tube containing a capillary tube in such a manner that the sealed part of the capillary was lying below the surface of the test substance and then set into the aluminium block. The block was heated with a quick heating rate. Heating was performed with a gas burner. All observations were observed.
A one-way aluminium crucible was prepared like described below. 2.85 mg test substance was weighed into a one-way aluminium crucible. The weight of the crucible with the test substance was recorded with 48.29 mg. The crucible was heated in the muffle furnace from room temperature to 450 °C.
After cooling down the crucible was inspected for visual changes and the weight of the crucible was recorded.
The DSC was calibrated for one-way aluminium crucibles with lid and a heating rate of 10 K/min using zinc and indium as standards.
An existing valid calibration was used (date: 16. Jan. 2018). The calibration was proved with indium (date: 19. Jun. 2018).
2.58 mg (first determination) and 2.89 mg (second determination) of the test item, respectively, were weighed into a one-way aluminium crucible and the crucible was closed with perforated aluminium lid using a capsule press. The mass of the crucible was documented.
The crucible containing the test item was heated under inert gas from 25°C to 340°C for the first determination and for the further determinations from 25 °C to 445 °C using a heating rate of 10 K/min. As reference an empty crucible of the same kind was used. The heat flow and temperature was recorded by the DSC during the test. After the test the appearance of the crucible was inspected for visual changes and the mass of the crucible was recorded.
The determination of the boiling point of Phosphoric acid, butyl ester was performed via DSC (differential scanning calorimetry).
In both DSC measurements two endothermic peaks were detected. Between those an exothermic behaviour was observed.
The beginning of decomposition from 240.8 °C was evaluated with event marker function. The melting point was evaluated with onset function. Therefore, the melting point of the decomposition product was determined as: 253.46 ± 0.33°C (526.61 ± 0.33 K)
The boiling point could not be determined under these test circumstances.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 103 (Boiling Point) and EU Method A.2 (Boiling Temperature)
- GLP compliance:
- no
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 3,3-bis(4-hydroxy-5-isopropyl-o-tolyl)phthalide
- EC Number:
- 204-729-7
- EC Name:
- 3,3-bis(4-hydroxy-5-isopropyl-o-tolyl)phthalide
- Cas Number:
- 125-20-2
- Molecular formula:
- C28H30O4
- IUPAC Name:
- 3,3-bis(4-hydroxy-5-isopropyl-o-tolyl)phthalide
- Details on test material:
- - Storage conditions: Room Temperature (20 ± 5 °C)
- Expiry date: 16. Dec. 2019
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- 253.46 °C
- Decomposition:
- yes
- Decomp. temp.:
- >= 240.8 °C
- Sublimation:
- no
- Remarks on result:
- other: melting point of the decomposition product was determined
Applicant's summary and conclusion
- Conclusions:
- In both DSC measurements two endothermic peaks were detected. Between those an exothermic behaviour was observed. The beginning of decomposition from 240.8 °C was evaluated with event marker function. The melting point was evaluated with onset function. Therefore, the melting point of the decomposition product was determined as: 253.46 ± 0.33°C (526.61 ± 0.33 K)
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