Registration Dossier

Administrative data

First-aid measures

- General advice:
Show the safety data sheet to the doctor in attendance.

- Following inhalation:
If breathed in, move person into fresh air.
If symptoms persist, call a physician.

- Following skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and water.
If symptoms persist, call a physician.

- Following eye contact:
Rinse immediately with plenty of water, also under the eyelids, for at least 5 minutes.
Remove contact lenses.
If eye irritation persists, consult a specialist.

- Following ingestion:
If swallowed, rinse mouth with water (only if the person is conscious).
Call a physician immediately.

- Most important symptoms and effects:
No information available.

Fire-fighting measures

- Suitable extinguishing media:
Water mist
Dry powder
Foam
Carbon dioxide (CO2)
Sand
Aqueous film forming foam (AFFF)
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

- Unsuitable extinguishing media:
Water spray jet

- Special hazards arising from the substance or mixture:
Hazardous combustion products:
Carbon oxides
Bromine compounds
Fluorine compounds
Nitrogen oxides (NOx)
Sulphur oxides

- Advice for fire fighter:
Special protective equipment for firefighters: In the event of fire, wear self-contained breathing apparatus.
Further information: In the event of fire, cool tanks with water spray. Avoid dust formation.

Accidental release measures

- Personal precautions:
Avoid dust formation
Avoid breathing dust
Evacuate personnel to safe areas
Keep away from open flames, hot surfaces and sources of ignition

- Protective equipment and emergency procedures:

- Environmental precautions:
Should not be released into the environment.
Do not flush into surface water or sanitary sewer system

- Methods and material for containment and cleaning up:
Large spills: Sweep up or vacuum with HEPA filter or via wet cleaning into suitable containers for disposal. Pick up and arrange without creating dust. Keep in properly labelled containers.
Small spills: Moisten a towel, cover the spill, pick up the spill or use HEPA vacuum.
Large spills + Small spills: Keep in suitable, closed containers for disposal. Treat recovered material as described for disposal considerations.

Handling and storage

- Precautions for safe handling:
Advice on safe handling:
Ensure all equipment is electrically grounded before beginning transfer operations.
To avoid thermal decomposition, do not overheat.
Use personal protective equipment as required.
Keep away from heat and sources of ignition.
Avoid inhalation, ingestion and contact with skin and eyes.
Avoid formation of dust and aerosols.

Advice on protection against fire and explosion:
Avoid dust formation.

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.

- Conditions for safe storage, including any incompatibilities:
Requirements for storage areas and containers:
To maintain product quality, do not store in heat or direct sunlight. Keep containers tightly closed in a dry, cool and well-ventilated place. Store in original container. Store at room temperature.

Recommended storage temperature: 15-25°C

Transport information

Land transport (ADR/RID)

UN number:
Not regulated as a dangerous good
Shippingopen allclose all
Class:
Not regulated as a dangerous good
Classification code:
Not regulated as a dangerous good
Packaging group:
Not regulated as a dangerous good
Labels:
Not regulated as a dangerous good
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
Not regulated as a dangerous good
Shippingopen allclose all
Class:
Not regulated as a dangerous good
Classification code:
Not regulated as a dangerous good
Packaging group:
Not regulated as a dangerous good
Labels:
Not regulated as a dangerous good
Remarksopen allclose all

Marine transport (IMDG)

UN number:
Not regulated as a dangerous good
Proper shipping name and description:
Not regulated as a dangerous good
Chemical name:
Not regulated as a dangerous good
Class:
Not regulated as a dangerous good
Packaging group:
Not regulated as a dangerous good
EmS code:
Not regulated as a dangerous good
Labels:
Not regulated as a dangerous good
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
Not regulated as a dangerous good
Proper shipping name and description:
Not regulated as a dangerous good
Chemical name:
Not regulated as a dangerous good
Class:
Not regulated as a dangerous good
Packaging group:
Not regulated as a dangerous good
Labels:
Not regulated as a dangerous good
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

1. Technical protection measures
Engineering measures:
Engineering controls should be used as the primary means to control possible exposures. Use process enclosures, local exhaust ventilation or other engineering controls to keep exposure levels below recommended exposure limits.
All personal protective equipment should be based on a risk assessment. Consult a Environment Health Safety expert if necessary.

Protective measures:
The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace

2. Organisational protection measures
Occupational protective measures:
3-bromo-5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine (CAS-No 1417421-99-8):
* value type (form of exposure): PBOEL-HHC
* control parameters: 2
* basis: J&J OEL/PBOEL HHC

J&J has a hazard banding notation: PBOEL HHC. This substance is classified by J&J as being PBOEL HHC 2. This means that the OEL is estimated to be from 20 to 100 µg/m3

3. Hand protection
Material: Nitrile rubber
Remark: Take note of the information given by the producer concerning permeability and break through times, and of special workplace conditions (mechanical strain, duration of contact). Impervious gloves

4. Feet protection

5. Body protection
Closed work clothing
Disposable one-piece overall

6. Eye protection
Safety glasses with side-shields

7. Respiratory protection
Engineering controls should always be the primary method of controlling exposures.
If respiratory protective equipment is needed for certain activities, the type as well as the corresponding protection factor will depend upon the risk assessment and air concentrations, hazards, physical and warning properties of substances present.
Use only respiratory protection that conforms to international/ national standards.
Suitable mask with particle filter P3

Stability and reactivity

1. Reactivity
None reasonably foreseeable.

2. Chemical stability
Stable under recommended storage conditions.

3. Possibility of hazardous reactions
Hazardous reactions: Risk of dust explosion.

4. Conditions to avoid
To avoid thermal decomposition, do not overheat.
Heat, flames and sparks.

5. Incompatible materials
Strong oxidizing agents

6. Hazardous decomposition products
Fluorocarbons, Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides, HBr

Disposal considerations

P501: Dispose of contents/ container to an approved waste disposal plant.