Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-985-0 | CAS number: 91031-79-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No acute toxicity studies with fatty acids, C9-13-neo-, copper salts are available, thus the acute toxicity will be addressed with existing data on the individual moieties copper and neodecanoic acid (being representative for fatty acids, C9-13-neo-).
Signs of acute oral and dermal toxicity are not expected for the moiety neodecanoic acid, since the LD50 is greater than 2000 mg/kg bw. The studies for moiety copper were assessed in a weight of evidence approach. The oral LD50 value is 197 mg Cu/kg bw. Further, copper sulphate is legally classified (Regulation 1272/2008; Index No. 029 -004 -00 -0) for acute oral toxicity category 4. The dermal LD50 value for copper is >2000 mg Cu/kg bw.
The calculated oral LD50 for fatty acids, C9-13-neo-, copper salts is 300 < LD50 <= 2000, thus the substance is classified according to regulation (EC) 1272/2008 for acute oral toxicity category 4 (H302: Harmful if swallowed).
The calculated dermal LD50 for fatty acids, C9-13-neo-, copper salts is >2000 mg/kg bw, thus the substance is not classified for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Copper
Acute oral toxicity
Three relevant and reliable GLP studies (Lheritier 1994, Sanders 2001a, Sanders 2002) tested different copper substances in regard to acute oral toxicity. All studies were used in a weight of evidence approach. Sanders (2002) assessed acute oral toxicity of copper oxide in rats conducting an OECD No.423 study. The test substance induced showed no systemic toxicity and a LD50 >2500 mg/kg bw was determined. In contrast, Lheritier (1994) and Sanders (2001a) showed comparable results in regard to acute oral toxicity for coppersulphateand coated copper flakes, respectively. In an OECD No. 401 study, Sanders (2001) estimated a LD50 in rats to be in the range of 300-500 mg/kg bw. Lheritier (1994) determined a LD50, for copper sulphate, in rats of about 481-482 mg/kg bw in a OECD No. 401 study.
Copper sulphate is characterized best and has a LD50 of 481 mg/kg bw. Based on the assumption that copper is the moiety of concern and responsible for adverse effects observed, a LD50 for copper of about 197.2 mg/kg bw could be calculated based on the molecular weight.
Moreover, copper sulphate is legally binding classified (Regulation (EC) No. 1272/2008; Index No. 029-004-00-0) for acute oral toxicity category 4 (H302: Harmful if swallowed).
Acute dermal toxicity
Three relevant and reliable GLP studies (Lheritier 1993, Sanders 2001b, Sanders 2002) tested different copper substances in regard to acute dermal toxicity. All studies were used in a weight of evidence approach. All studies were performed in rats according to OECD test guideline No. 402. None of the copper substances tested showed acute dermal toxicity and, thus LD50 was determined to be greater than 2000 mg/kg bw. All studies were used in a weight of evidence approach. The LD50 for copper salt is set accordingly to be greater than 2000 mg/kg bw.
Neodecanoate
Neodecanoic acid has a low potential for toxicity via the oral and dermal routes.
Oral
Male and female rats were gavaged with neodecanoic acid at concentrations of 1, 1.5, 2, 3, or 4 ml/kg to assess acute oral toxicity. All animals that died during the study did so within 3 days of exposure. Signs of toxicity included lethargy, hypothermia, piloerection, dyspnea, and ataxia. Based on these results, it is concluded that the LD50 is approximately 2.27 ml/kg (2066 mg/kg).
Dermal
In a study that assessed acute dermal toxicity, male and female rats were exposed to 4 ml/kg (3640 mg/kg) neodecanoic acid via an occluded dermal patch for 24 hours. After 24 hours, the patch was removed and clinical observations were made once daily for 9 days. There were no deaths observed in this study and there were no signs of a toxicity response. It is concluded that the LD50 is greater than 3640 mg/kg.
Fatty acids, C9-13-neo-, copper salts
No acute toxicity studies with fatty acids, C9-13-neo-, copper salts are available, thus the acute toxicity will be addressed with existing data on the individual moieties copper and neodecanoic acid (being representative for fatty acids, C9-13-neo-).
The oral LD50 for fatty acids, C9-13-neo-, copper salts is based on the LD50 values of the assessment entities copper and neodecanoic acid. Based on the oral LD50 value for copper of 197 mg Cu/kg bw and the oral LD50 values of neodecanoic acid of >2000 mg/kg bw, the calculated LD50 for fatty acids, C9-13-neo-, copper salts is 300 < LD50 <= 2000, thus the substance is classified according to regulation (EC) 1272/2008 for acute oral toxicity category 4 (H302: Harmful if swallowed).
The dermal LD50 for fatty acids, C9-13-neo-, copper salts is based on the LD50 values of the assessment entities copper and neodecanoic acid. Based on the dermal LD50 value for copper of >2000 mg Cu/kg bw and the dermal LD50 value of neodecanoic acid of >2000 mg/kg bw, the calculated dermal LD50 for fatty acids, C9-13-neo-, copper salts is >2000 mg/kg bw, thus the substance is not classified for acute dermal toxicity.
For further information on the toxicity of the individual moieties, please refer to the relevant sections in the IUCLID and CSR.
Justification for classification or non-classification
The calculated oral LD50 for fatty acids, C9-13-neo-, copper salts is 300 < LD50 <= 2000, thus the substance is classified according to regulation (EC) 1272/2008 for acute oral toxicity category 4 (H302: Harmful if swallowed).
The calculated dermal LD50 fatty acids, C9-13-neo-, copper salts is >2000 mg/kg bw, thus the substance is not classified for acute oral toxicity.
No adverse effects were observed upon necropsy in the acute oral toxicity studies with the assessment entity copper or neodecanoic acid (being representative for fatty acids, C9-13-neo-) that would justify a classification for specific target organ toxicity-single exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.