Registration Dossier
Registration Dossier
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EC number: 266-803-5 | CAS number: 67634-00-8
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR
The hydrolysis QSAR prediction was assessed as adequate for regulatory purposes (Klimisch 2 – results derived from a valid QSAR model and falling into its applicability domain, with adequate and reliable documentation/justification). - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
- Transformation products:
- not specified
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- ca. 2.2 d
- Type:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- ca. 22 000 d
- Type:
- not specified
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 22 d
- Type:
- not specified
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 0.22 d
- Type:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Hydrolysis as a function of pH (EPI Suite)
Kb = 3.653 L/mol-sec
HL*(pH 8) = 2.2 days
HL (pH4) = 22,000 days/ 60.3 years
HL (pH 7) = 22 days
HL (pH 9) = 0.22 days - Executive summary:
Hydrolysis as a function of pH (EPI Suite)
Kb = 3.653 L/mol-sec
HL*(pH 8) = 2.2 days
HL (pH4) = 22,000 days/ 60.3 years
HL (pH 7) = 22 days
HL (pH 9) = 0.22 days
Reference
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 22 d
- at the temperature of:
- 25 °C
Additional information
Hydrolysis as a function of pH (EPI Suite)
Kb = 3.653 L/mol-sec
HL*(pH 8) = 2.2 days
HL (pH4) = 22,000 days/ 60.3 years
HL (pH 7) = 22 days
HL (pH 9) = 0.22 days
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