Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- ICP/OES
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus, clone number 5, from at least the third generation (i.e. the third brood) obtained with a non-cyclic parthenogenesis reproduction.
Study design
- Test type:
- static
- Water media type:
- other: ultrapure water
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 210 mg/L of CaCO3
- Test temperature:
- 19.8 – 20.0°C
- pH:
- 7.9
- Dissolved oxygen:
- 8.8 mg/L
- Nominal and measured concentrations:
- Water Accomodated Fractions (nominal concentrations): 55, 324, 1050 mg/L.
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- ca. 319.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EL50
- Effect conc.:
- ca. 956.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results obtained for the test item “W3803S04SOLSIV” on the toxicological endpoint “immobilisation” gave an EL50-24h = 956.5 mg/L [696.6– 1657.6] and an EL50-48h = 319.7 mg/L [257.9 – 404.4] based on nominal test item loading rate.
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