Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 688-270-1 | CAS number: 16133-25-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- not specified
- Remarks:
- migrated information
- Adequacy of study:
- weight of evidence
- Study period:
- 1964
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Basic details provided, Single dose study involving male animals only. Limited parameters were evaluated
- Justification for type of information:
- Basic details provided, Single dose study involving male animals only. Limited parameters were evaluated
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Influence of Nicotinic, Picolinic and Pyridine-3-sulfonic Acids on Cholesterol Metabolism in the Rat
- Author:
- Kritchevsky D and Tepper SA
- Year:
- 1 964
- Bibliographic source:
- J. Nutr. January 1, 1964 vol. 82 no. 1 157-161
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals were treated with test substance through dietary administration for three weeks and observed for limited parameters including mortality, body weight, food consumption and liver weight.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Limit test:
- no
Test material
- Reference substance name:
- Pyridine-3-sulphonic acid
- EC Number:
- 211-265-9
- EC Name:
- Pyridine-3-sulphonic acid
- Cas Number:
- 636-73-7
- Molecular formula:
- C5H5NO3S
- IUPAC Name:
- pyridine-3-sulfonic acid
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Pyridine-3-sulfonic acid
- Molecular formula: C5-H5-N-O3-S
- Molecular weight: 159.165
- Smiles notation: S(c1cnccc1)(=O)(=O)O
- Substance type: Pure active substance
No further details were provided in the publication
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-160g
- Diet: Rats were fed on the basal test diet or control diet (ad libitum), as described under 'Details on oral exposure'.
No further details on test animal were provided
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: diet admixed
- Details on oral exposure:
- DIET PREPARATION:
Test diet: The basal test diet contained, per 100g: cereal mixture 70g; wheat germ 6.25g; skim milk powder 20g; vitamin mixture 2.75g; and test compound 1.0g. Sufficient water was added to make a thick dough.
Control diet: The control diet contained 70g of cereal mixture.
- No further details were provided in the publication - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 weeks
- Frequency of treatment:
- Continuously in diet (ad libitum)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 and 1%
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5 males/dose group
- Control animals:
- other: control diet (refer to details on oral exposure)
- Details on study design:
- No details were provided in the publication
- Positive control:
- no
Examinations
- Observations and examinations performed and frequency:
- - Animals were observed for Mortality, Body weight gain and Food consumption
- Sacrifice and pathology:
- - All surviving animals were sacrificed on completion of the 3 week treatment period. No relevant pathological examination were performed
- Other examinations:
- - Organ weight: Liver weight was examined for all experimental animals
- Statistics:
- Findings were presented as group mean value with standard deviations
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- No mortality was noted
- Mortality:
- no mortality observed
- Description (incidence):
- No mortality was noted
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- not examined
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- MORTALITY
- All experimental animals survived to the scheduled sacrifice
BODY WEIGHT AND WEIGHT GAIN
- The control group exhibited a greater body weight gain than did the test group. However, this difference was not statistically significant.
FOOD CONSUMPTION AND COMPOUND INTAKE
- No anorexia (as evidenced by reduced weight gain) was observed in any group
ORGAN WEIGHTS
- Group mean Liver weight of test group was low when compared to the control group. However, this difference was not statistically significant.
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 900 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: No significant differences observed in mortality; body weight; food consumption; and organ weights (liver) of test animals
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Administration of test substance to male wistar rats at dose level of 1% in diet (equivalent to 900 mg/kg bw/day) for 3 weeks, did not produce any adverse effects attributable to treatment with test substance. Under the conditions of this study, NOAEL was determined to be 900 mg/kg bw/day.
- Executive summary:
Male wistar rats were treated with test substance at dose level of 1% in diet (equivalent to 900 mg/kg bw/day) for 3 weeks and observed for limited parameters including mortality, body weight, food consumption and liver weight. Group of animals that received basal untreated diet, served as control.No treatment related adverse effects were observed. Under conditions of this study, NOAEL was determined to be 900 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.