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EC number: 807-935-0 | CAS number: 1244733-77-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The irritant/corrosive potential of the test substance TCPP was studied on the skin of the rabbit in accordance with the OECD Guideline No. 404 for testing of Chemicals (Martins, Bayer AG, 1991; IRI, 1989c). The results of this experiment indicate that the test substance is not irritating to the skin.
The irritant/corrosive potential of the test substance TCPP was studied on the eye of the rabbit in accordance with the OECD Guideline No. 405 for testing of Chemicals (Martins, Bayer AG, 1991). The results of this experiment indicate that the test substance is not irritating to the eye.
Hazards identified by EU Assessment in May 2008:
"There is an extensive database in animals, indicating that TCPP is non-irritant in the rabbit eye and skin. The lack of any substantial skin or eye irritation and the lack of irritation observed in the acute inhalation studies suggest that TCPP would be unlikely to produce significant respiratory tract irritation."
Additional information:
TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating (Kimmerle G., 1973).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed to GLP. Endpoint study record transfered from EU Risk Assessment Report 2008.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Tolgard TMCP
received 30 November 1988
colourless liquid
stored in the dark under ambient conditions - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Cheshire Rabbit Farms Ltd, Tarporley
- Age at study initiation: not given
- Weight at study initiation: not given
- Housing:individually in aluminium cages
- Diet (e.g. ad libitum): Rabbit Diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: minimum of 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-20C
- Humidity (%): 49%
- Air changes (per hr): not given
- Photoperiod (hrs dark / hrs light):12h light/ dark cycle
IN-LIFE DATES: From: 18 Jnauary 1989 To: 22 January 1989 - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml of test material was applied to the intact, clipped skin of three rabbits under a 2.5 cm x 2.5 cm patch of gauze.
- Duration of treatment / exposure:
- At the end of the 4 hour exposure period the patches were removed, the test sites were wiped carefully with water-moistened tissues.
- Observation period:
- The skin reactions were assessed 1, 24, 48 and 72 hours after patch removal using the OECD recommended scoring system.
- Number of animals:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- Oedema formation was not recorded in any of the animals. Well-defined erythema was recorded at two treated sites, with very slight erythema at one site 1 hour after patch removal. By 24 hours, all treated sites showed very slight erythema and all sites were normal 48 hours after patch removal. TCPP produced mild transient skin irritation, which was fully reversible by 48 hrs.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- IUCLID4 Test substance: other TS
TS-Freetext:
Tris chloroisopropyl phosphate purity 97.85% including all
isomers as per 1.1 - 1.4.
- Name of test material (as cited in study report): Tris-chlorisopropylphosphat
- Molecular formula (if other than submission substance): C9H18Cl3O4P
- Molecular weight (if other than submission substance): 327.6
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: colourless clear liquid
- Analytical purity: 97.85%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 002871/1989 of 13.12.1989 production process sample
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: guarenteed for test period
- Storage condition of test material: room temperature in dark
- Other: pH 3.7 - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd, Huntingdon
- Age at study initiation: not given
- Weight at study initiation: 3.4-3.5 kg
- Housing:individually in stainless steel or plastic cages
- Diet (e.g. ad libitum): Standard diet Ssniff K 4 100-120 g/day
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period:at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-3C
- Humidity (%): apprx 50%
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light):12 hours light/dark cycle
IN-LIFE DATES: From:8-January-1991 To:15 January 1991 - Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: treated animals served also as control
- Amount / concentration applied:
- A volume of 0.5 ml of the test material was applied via a patch to the shaved skin (6cm2) of each of three rabbits. A further patch, moistened with water was also applied on the opposite shaved dorso-lateral area of the trunk.
- Duration of treatment / exposure:
- After an exposure period of 4 hours, patches and dressing were removed and the treated sites were carefully washed with water.
- Observation period:
- Dermal irritation was scored (following the OECD recommended scoring system) and recorded at termination of exposure as well as 1 hr, 24 hrs, 48 hrs, 72 hrs, 7 days and 14 days after exposure.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2
- % coverage:
- Type of wrap if used: Hansamed patch held in place with Fixonmull semiocclusive dressing Beiersdorf
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The test substance did not cause oedema formation in any of the animals (primary irritation score 0). Well-defined erythema (score 2) was evident at the test site of two rabbits 1 hour after termination of exposure but by 24 hrs only slight erythema was evident (score 1) and all evidence of erythema formation had disappeared by 48 hrs. In the other rabbit, slight erythema was observed at 1 hr but had disappeared by 24 hrs. The mean skin irritation index for each of the two most sensitive rabbits was 0.3. TCPP therefore does not have a local irritant potential in the rabbit skin.
- Other effects:
- no data
- Executive summary:
The irritant/corrosive potential of the test substance TCPP was studied on the skin of the rabbit in accordance with the OECD Guideline No. 404 for testing of Chemicals.
The results of this experiment indicate that the test substance is not irritating to the skin.
The substance does not have a significant local irritating potential to the skin.
Referenceopen allclose all
Test for irritant effect on the skin (expos.: 4hrs)
Animal No.: | Body weight | Draize grade after | Irritat.Index | ||||||||||||
1h | 24h | 48h | 72h | 7d | 14d | ||||||||||
e | o | e | o | e | o | e | o | e | o | e | o | e | o | ||
M20 | 3,4 kg (female) | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | 0,3* | 0,0 |
M25 | 3,4 kg (female) | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | 0,0 |
M8 | 3,5 kg (female) | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | 0,3* | 0,0 |
e = erythema and eschar formation
o = oedema formation
- = not examined
* 0,3 = no irritation (irritation index 0,0 to 0,99)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- IUCLID4 Test substance: other TS
TS-Freetext:
Tris chloroisopropyl phosphate purity 97.85% including all
isomers as per 1.1 - 1.4.
- Name of test material (as cited in study report): Tris-chlorisopropylphosphat
- Molecular formula (if other than submission substance): C9H18Cl3O4P
- Molecular weight (if other than submission substance): 327.6
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: colourless clear liquid
- Analytical purity: 97.85%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 002871/1989 of 13.12.1989 production process sample
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: guarenteed for test period
- Storage condition of test material: room temperature in dark
- Other: pH 3.7 - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd, Huntingdon
- Age at study initiation: not given
- Weight at study initiation: 3.6-3.7 kg
- Housing:individually in stainless steel or plastic cages
- Diet (e.g. ad libitum): Standard diet Ssniff K 4 100-120 g/day
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period:at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-3C
- Humidity (%): apprx 50%
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light):12 hours light/dark cycle
IN-LIFE DATES: From:8-January-1991 To:15 January 1991 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: treated animals served also as control (one eye TCPP, the other remained untreated and served as control)
- Amount / concentration applied:
- 100 µl TCPP in one eye.
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- A volume of 0.1 ml of the test material was instilled into the conjunctival sac of one eye of each of three rabbits. The other eye remained untreated and served as control. The treated eyes were rinsed with saline 24 hours post-treatment.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- There were no signs of irritation in any of the treated eyes at any of the observation times of 24, 48 and 72 hours. One animal had evidence of aqueous humour discharge at 48 hours, but this did not persist.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not considered irritating to the eye.
- Executive summary:
The irritant/corrosive potential of the test substance TCPP was studied on the eye of the rabbit in accordance with the OECD Guideline No. 405 for testing of Chemicals.
The results of this experiment indicate that the test substance is not irritating to the eye.
The substance does not have a significant local irritating potential to the eye.
Reference
Test for irritant effect on the eye (expos.24hrs):
Animal No.+Body weight | Tissue | Signs | Draize grades | |||||||
M5, female (3,7 kg) | 1h | 24h | 48h | 72h | 7d | 14d | 21d | Irritation index | ||
cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
a | 0 | 0 | 0 | 0 | 0 | - | - | |||
fluorescein | i | - | 0 | - | - | - | - | - | ||
a | - | 0 | - | - | - | - | - | |||
iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
discharge | 1 | 0 | 0 | 0 | 0 | - | - | |||
L25, female(3,6 kg) | cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 |
a | 0 | 0 | 0 | 0 | 0 | - | - | |||
fluorescein | i | - | 0 | - | - | - | - | - | ||
a | - | 0 | - | - | - | - | - | |||
iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
discharge | 0 | 0 | 0 | 0 | 0 | - | - | |||
1 | 0 | 2 | 0 | 0 | - | - | ||||
L14, female(3,7 kg) | cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 |
a | 0 | 0 | 0 | 0 | 0 | - | - | |||
fluorescein | i | - | 0 | - | - | - | - | - | ||
a | - | 0 | - | - | - | - | - | |||
iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
discharge | 1 | 0 | 0 | 0 | 0 | - | - |
o = opacity
a = area
i = intensity
r = redness
s = swelling
- = not examined
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
EU Risk Assessment of 2008: "Based on the available studies, TCPP needs no classification for irritation according to EU guidelines."
Update March 2018: The conclusion of non-classification for irritation is confirmed and compliant with EU Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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