Cyclohexane, 1,3-bis(isocyanatomethyl)-

Endpoint summary

Link to relevant study record(s)

Reference

Endpoint:

basic toxicokinetics

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.

Justification for type of information:

The rationale to read across the data is attached in section 13.

Reason / purpose for cross-reference:

read-across source

Type:

absorption

Results:

For risk assessment purposes, 100% is used for oral, dermal and inhalation absorption

Conclusions:

A toxicokinetic assessment was performed based on the available data of 1,4-H6XDI. Based on the physical/chemical properties of 1,4-H6XDI, absorption factors are derived to be 100% (oral, inhalation and dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low. These conclusions are read across to 1,3-H6XDI.

Description of key information

A toxicokinetic assessment was performed based on the available data of 1,4-H6XDI. Based on the physical/chemical properties of 1,4-H6XDI, absorption factors are derived to be 100% (oral, inhalation and dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low. These conclusions are read across to 1,3 -H6XDI.

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

100

Absorption rate - inhalation (%):

100