Reaction products of m-phenylenebis(methylamine) with 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 October 2017 - 23 March 2018

Reliability:

1 (reliable without restriction)

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)

GLP compliance:

yes

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3- epoxypropane, reaction products with mphenylenebis(methylamine)

Cas Number:

113930-69-1

IUPAC Name:

4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3- epoxypropane, reaction products with mphenylenebis(methylamine)

Test material form:

solid

Details on test material:

- Physical appearance: light amber solid
- Storage of test material: at room temperature

Study design

Analytical method:

other: UV

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Remarks on result:

not determinable because of methodological limitations

Details on results:

Preliminary study:
Based on the observation of undissolved test item in the n-octanol solution, it was concluded that the n-octanol solubility of the test item is < 10 mg/L.

Main study:
The maximum concentration analyzed was 0.00038 g/L at a loading rate of 25 mg/L. Based on this it was concluded that the n-octanol solubility of the test item is < 1 mg/L.
See results in Table 1

The water solubility was found to be < 10 mg/L. The n-octanol solubility of the test item was found to be < 1 mg/L. Pow and log Pow of the test item at 20°C cannot be determined using these solubilities in water and n-octanol.
The Shake flask method, the HPLC method and the Calculation method are not applicable either.

Any other information on results incl. tables

Table 1: n-Octanol solubility of the test item

 

Loading rate   mg/L	Stirring time [hours]	Absorbance [AU]	Absorbance corrected [AU]	Weight of subsamples g	Analyzed Concentration g/kg	Analyzed Concentration g/L
0	72	0.0040		16516
0	72	0.0011		16508
0	72	0.0037		16506
25	24	0.0073	0.00437a	16504	1.3x10^-4	0.00010b
25	48	0.0140	0.0111a	16504	3.5x10^-4	0.00029b
25	72	0.0172	0.0143a	16505	4.6x10^-4	0.00038b

a)The absorbance of the samples is corrected with the average response of the blank i.e. 0.00293 AU (n=3)

b)Estimated value, calculated by extrapolation of the calibration curve

Applicant's summary and conclusion

Conclusions:

It is technically not possible to determine the partition coefficient (Pow) of INCA 460: MXDA.