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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
48 hours
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
The read-across from Mn salts is justified on the basis that these substances are very soluble in water and both will dissociate to release Mn2+ ions. The anions are not considered to have any influence on the effective toxicity of Mn2+ and as demonstrated with the algal study, the toxicity of the substance to invertebrates can be estimated based on known effects of Mn 2+ metal
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across source
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Principles of method if other than guideline:
Principles of method followed, but using different species
Up to 96 hours acute test on < 24 hr old organisms.
Toxicity examined in three different levels of hardness
GLP compliance:
not specified
Remarks:
Academic research
Analytical monitoring:
yes
Details on sampling:
Samples at start and end of testing on highest and lowest concentrations
Vehicle:
no
Test organisms (species):
Ceriodaphnia dubia
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
Three levels of hardness:
Soft = 26 mg/l
Medium = 92 mg/l
Hard = 184 mg/l
Test temperature:
25 C
pH:
8 - 8.4
Nominal and measured concentrations:
Nominal Concentrations 2.5, 5, 10, 20, 40, 80 mg/l as Mn 2+
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
ca. 34 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Remarks:
Estimated for Manganese glycinate based on Mn toxicity
Basis for effect:
mobility
Remarks on result:
other: Medium water (ie within guideline level)
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
13.7 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Mn 2+
Basis for effect:
mobility
Remarks on result:
other: Hard water
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
8.6 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Mn 2+
Basis for effect:
mobility
Remarks on result:
other: Medium hardness
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
3 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Mn
Basis for effect:
mobility
Remarks on result:
other: Soft water
Details on results:
Important to note that the toxicity was greatest in the soft water.
This is in line with fish toxicity testing
Validity criteria fulfilled:
not specified
Conclusions:
The toxicity to Manganese was greatest in soft water and confirms toxicity vs hardness relationship seen with fish.

Description of key information

The aquatic toxicity for the target is predicted at level EC50 34 mg/l based on the toxic effect of Mn

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
ca. 34 mg/L

Additional information