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Diss Factsheets
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EC number: 947-819-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted 13. April 2004;
resp. EU A.8 - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Bruggolen® H3301
Batch no. 16101213
Production date 12. Oct. 2016
Expiry date 12. Oct. 2026 - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. 5.5
- Temp.:
- 25 °C
- pH:
- ca. 6
- Conclusions:
- Variations in the retention times of reference items and test item are very small. Therefore a stable configuration of the HPLC-column can be assumed.
The correlation log k/log POW is good: the coefficient of determination r2 was calculated with 0.9934. This value was considered as sufficiently high to use the calibration function for the determination of the log POW of the test item Iodobis(triphenylphospino)copper.
Using the correlation log k / log POW, the log POW of test item Iodobis(triphenylphospino)copper was calculated as 5.50 ± 0.00 (mean ± standard devia-tion).
No observations were made which might cause doubts concerning the validity of the study outcome. - Executive summary:
The study was performed using a HPLC with a C18 column.Eightreference items with different retention times and thiourea for the determination of the dead time were used to produce a calibration curve, since retention time on hydrophobic columns and POWare correlated. The reference items were chosen based on the results of the pre-test.
One vial was filled with the reference item mix and one vial with the test item solution. The vials were analysed using the HPLC with the program described below. First one injection from the solvent blank methanol/water 75/25 % (v/v) was made. Then three injections were measured from the reference item mix, three injections from the test item and again three injections from the reference item mix.
For each reference item, the capacity factor k was calculated from the retention time of thiourea and the retention time of the respective reference item.A calibration function (log k versus log POW, linear fit) was determined using the literature values for POWof the reference items and the retention times in the six determinations.
With the calibration function log k versus log POW, the corresponding log POWvalues of the peak was determined:
Using the correlation log k / log POW, the log POWof test itemIodobis(triphenylphospino)copperwas calculated as
5.50 ± 0.00
(mean ± standard deviation of three independent determinations).
Reference
Measurement Data
The retention times (RT) of the test item are presented in the following table:
Measurement | RT (min) |
Measurement 1 | 19.074 |
Measurement 2 | 19.100 |
Measurement 3 | 19.134 |
Mean | 19.102 |
Standard deviation | 0.030 |
Calculated values
The calculated values are presented in the following table:
Measurement | Capacity Factor k | log Capacity Factor log k | log POW |
Measurement 1 | 12.6448 | 1.1019 | 5.493 |
Measurement 2 | 12.6637 | 1.1026 | 5.495 |
Measurement 3 | 12.6877 | 1.1034 | 5.497 |
Mean | 5.495 | ||
Relative Standard deviation | 0.002 |
log POWwas calculated from the capacity factor as follows:
log POW= (log k + 0.7919) / 0.3448
Using the correlation log k / log POW, the log POWof test itemIodobis(triphenylphospino)copperwas calculated as 5.50 ± 0.00 (mean ± standard deviation).
Description of key information
The log POW of test item Iodobis(triphenylphospino)copper was calculated as 5.50 ± 0.00.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.5
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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