4'-Ethyl-3-fluorbiphenyl-4-boronic acid

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03.08.06 - 18.01.07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Temp.:

20 °C

Vapour pressure:

0 Pa

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

Temp.:

50 °C

Vapour pressure:

0 Pa

The vapour pressure was measured in the temperature range of 25 °C to 116 °C. Above 76 °C a vapour pressure could be measured. The measured vapour pressures at the corresponding temperatures are listed in the following table:

Temperature / °C	Vapour pressure / hPa
75.7	3.9 x 10E-5
82.6	1.9 x 10E-4
87.8	8.8 x 10E-4
90.7	2.1 x 10E-3
93.4	3.8 x 10E-3
96.8	3.3 x 10E-3
97.2	3.9 x 10E-3
100.3	3.8 x 10E-3
109.3	6.1 x 10E-3
115.7	8.0 x 10E-3

The course of the vapour pressure as a function of the inverse temperature shows an untypical profile. At the beginning of the measurement the test item is a solid up to a temperature of approximately 95°C. Above 95°C the test item started to melt. The data points at 96.8 - 115.7°C show the melting of the test item accompanied by the decomposition of the product, which influenced the vapour pressure. Due to this the regression according to the Antoine equation was only performed for the vapour of the solid product (75.7 - 93.4°C).

The values for 20, 25 and 50°C are calculated, using the Antoine constants A, B and C.

The following vapour pressure values for the test item were extrapolated from the experimental data

(vapour pressure: effusion method):

 

T/°C	p/hPa	p/Pa
20	3.6 x 10E-13	3.6 x 10E-11
25	2.5 x 10E-12	2.5 x 10E-10
50	1.6 x 10E-8	1.6 x 10E-6

Conclusions:

The vapour pressure of the test item was determined to be 3.6E-11 Pa at 20 °C, 2.5E-10 Pa at 25 °C and 1.6E-6 Pa at 50 °C, respectively.

Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 20 and 115.7 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be 3.6E-11 Pa at 20 °C, 2.5E-10 Pa at 25 °C and 1.6E-6 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 3.6E-11 Pa at 20 °C, 2.5E-10 Pa at 25 °C and 1.6E-6 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 20 and 115.7 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be3.6E-11 Pa at 20 °C, 2.5E-10 Pa at 25 °C and 1.6E-6 Pa at 50 °C, respectively.