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EC number: 640-410-2 | CAS number: 2594-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-11-15 to 2004-12-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 24 April 2002
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- A mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime
- EC Number:
- 460-110-3
- EC Name:
- A mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime
- IUPAC Name:
- A mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime
Constituent 1
- Specific details on test material used for the study:
- - Name: "WASOX-MMAC2"
- Batch No.: 1000024854
- Purity: The test substance is a mixture of mainly 3 components:
MMAC2 (range: 45-80% w/w), accurately 55.0% (GC-% w/w),
MM2AC (range 2-30% w/w), accurately 11.7% (GC-% w/w) and
MAC3 (range 5-30% w/w),accurately 24.0% (GC-% w/w) plus by-products and impurities.
The 3 components act uniformly as hardeners for silicone sealing masses. They polymerise, triggered bv hydrolysis.
- CAS No. (main component): 72122-57-7
- Solubility in water: Poorly soluble. A polymeric, insoluble in water, is formed by hydrolysis. Rapid onset of hydrolysis.
- Solubility in other solvents: Easily soluble in toluene and methylcyclohexane
- Appearance: Solid and liquid parts at room temperature.Yellowish brownish colour.
- Melting point: 30 - 35 °C.
- Conditions of storage: Storage under a nitrogen atmosphere, as the substance reacts with water, even from air humidity. Ambient temperature (theoretically up to approx. 40 °C possible), protected against light (handling without protection against light is acceptable).
- Handling precautions: Exothermic reaction with water or humidity from the air.
- Date of expiry: December 2005
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, 97633 Sulzfeld, Germany
- Weight at study initiation: Animal No. 1: 1.8 kg, Animal No. 2: 2.1 kg and Animal No. 3: 2.1 kg
- Housing: Individual caging in metal wire cages
- Diet (e.g. ad libitum): Yes, Altromin 2123 maintenance diet for rabbits
- Water (e.g. ad libitum): Yes, tap water
- Acclimation period: 5 days (animal No. 1) and 12 days (animals Nos. 2 and 3)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Average of 19.2
- Humidity (%): Average of 50.1
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- The first patch was removed after 3 minutes. As there was no serious skin reaction observed, a second patch was applied at a different site and removed after 1 hour. Because there was still no serious skin reaction noted, a third patch was applied and removed after 4 hours.
- Observation period:
- 1, 24, 48 and 72 hours after patch removal
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm, the test sites were meian on the dorsal thoracal region
- Type of wrap if used: the cellular patches with the test item were held in place by fixing them marginally with non-irritating tapes. The application sites were covered semiocclusively by a dressing. Access by the animals to the application sites was prevented by a plastic collar.
Test Procedure:
Initial test:
First the test substance was administered to one animal in a sequential manner. Three patches, each 0.5 mL of the test substance, were applied sequentially to the animal. The first patch was removed after 3 minutes. As there was no seious skin reaction observed, a second patch was applied at a different site and removed after one hour. Because there was still no serious skin reaction noted, a third patch was applied and removed after 4 hours.
Confirmatory Test:
As no corrosive effect was observed in the initial test, the test substance was adminsitered to two additional animals, each with one patch, one week later for an exposure period of 4 hours.
Skin examinations:
The skins of the animals were examined for local alterations one day before the administration of the test substance (after clipping of the hair) and immediately before the administration. The treated areas of the animals were examined for erythema/eschar and oedema as well as for other local alterations (such as hyperplasia, scaling, discolouration, fissues, scabs and alopecia) approximately 1, 24, 48 and 72 hours after patch removal.
No further examinations were performed thereafter. The 3 minutes, 1 hour and 4 exposure sites of the first animal were examined immediately after the end of the exposure time. No further examinations were performed thereafter for the 3 minutes and 1 hour test sites. The skin was examined using a cold light source KL 1500 electronic.
The following scoring scheme were applied:
Erythema and eschar formation:
0 - No erythema
1 - Very slight erythema (barely perceptible)
2 - Well-defined erythema
3 - Moderate to severe erythema
4 - Severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema formation:
0 - No oedema
1 - Very slight oedema (barely perceptible)
2 - Slight oedema (edges of area well-defined by definite raising)
3 - Moderate oedema (raised approximately 1 millimetre)
4 - Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- All areas to be treated with the test substance and alt contral areas were normal before the application and at each observation time. Moreover, no symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results from a primary dermal irritation study conducted according to OECD guideline 404, the test item WASOX-MMAC2 can be considered as non-irritant to the skin.
- Executive summary:
In a primary dermal irritation study conducted according to OECD guideline 404, 0.5 mL of the test item was applied to three New Zealand White rabbits for 4 hours under semi-occlusive conditions to a body surface area of 2.5 cm². Skin reactions were scored approximately 1, 24, 48 and 72 hours after patch removal. The test item did not cause any skin effects and is considered under the conditions of this study as nontoxic.
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