2-fluorobenzoyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

not specified

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)

Deviations:

not specified

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-fluorobenzoyl chloride

EC Number:

206-887-2

EC Name:

2-fluorobenzoyl chloride

Cas Number:

393-52-2

Molecular formula:

C7H4ClFO

IUPAC Name:

2-fluorobenzoyl chloride

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

2000 mg/Kg (volume of 10 ml/Kg)

No. of animals per sex per dose:

3

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

One male animal was found dead on test day 2.

Clinical signs:

other: Sedation, rolling spasms, ventral recumbency, hunched posture and dyspnea were only observed in male animals whereas ruggled fur was observed in male and female animals. No clinical signs were observed in one out of three males during the observation peri

Gross pathology:

Dark-red isolated foci on the right caudal lobe of the lungs, yellowish discoloration in esophagus and jejunium, yellowish liquid content in the jejunium, light-brown ileum distended with gas, balck-brown content in the stomach and ileum, clotted blood in the stomach, violed discoloraration and hardened caecum withwas reduced in size and gray-white discoloration in the colon and rectum were noted in one male animal which died spontaneously. At scheduled necropsy, no macroscopic findinings were obsaerved.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The DL50 of the substance after single oral administration to rats of both sexes, observed over a period of 14 days, is greater than 2000 mg/Kg b.w.