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EC number: 243-606-2 | CAS number: 20217-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January - May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [(2,4-dibromophenoxy)methyl]oxirane
- EC Number:
- 243-606-2
- EC Name:
- [(2,4-dibromophenoxy)methyl]oxirane
- Cas Number:
- 20217-01-0
- Molecular formula:
- C9H8Br2O2
- IUPAC Name:
- 2-[(2,4-dibromophenoxy)methyl]oxirane
- Reference substance name:
- 2,4-dibromophenol
- EC Number:
- 210-436-5
- EC Name:
- 2,4-dibromophenol
- Cas Number:
- 615-58-7
- Molecular formula:
- C6H4Br2O
- IUPAC Name:
- 2,4-dibromophenol
- Reference substance name:
- [(p-bromophenoxy)methyl]oxirane
- EC Number:
- 218-656-3
- EC Name:
- [(p-bromophenoxy)methyl]oxirane
- Cas Number:
- 2212-06-8
- Molecular formula:
- C9H9BrO2
- IUPAC Name:
- 2-[(4-bromophenoxy)methyl]oxirane
- Reference substance name:
- [(2,4,6-tribromophenoxy)methyl]oxirane
- EC Number:
- 226-140-4
- EC Name:
- [(2,4,6-tribromophenoxy)methyl]oxirane
- Cas Number:
- 5296-40-2
- Molecular formula:
- C9H7Br3O2
- IUPAC Name:
- 2-[(2,4,6-tribromophenoxy)methyl]oxirane
- Test material form:
- liquid
- Details on test material:
- sample used for testing,
no further details
Constituent 1
impurity 1
impurity 2
impurity 3
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: CG272
- Expiration date of the lot/batch: 11. July 2018
- Purity test date: not stated
RADIOLABELLING INFORMATION (if applicable)
not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: solubility in water: 68.3 mg/L in water, stability to be tested
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: assumed not reactive
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from a biologic sewage treatment plant was used. The chosen plant is treating mostly domestic sewage.
The sludge was taken from the activation basin of the ESN (Stadtentsorgung Neustadt)
sewage treatment plant, Im Altenschemel, NW-Lachen-Speyerdorf.
Date of collection: 20. Jan. 2017, batch no: 20170120.
- Laboratory culture: not applicable
- Method of cultivation: not applicable
- Storage conditions: re-suspended in test medium. It was then aerated until use.
- Storage length: few days
- Preparation of inoculum for exposure:
- Pretreatment: The sludge was filtrated, washed with tap water (2x), then washed with and re-suspended in test medium. It was then aerated until use.
- Concentration of sludge: The dry matter was determined as 5000 mg suspended solids/L.
- Initial cell/biomass concentration:
- Water filtered: yes
- Type and size of filter used, if any:not stated - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- >= 56.8 - <= 58.5 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to Guideline
- Additional substrate: none
- Solubilising agent (type and concentration if used): none
- Test temperature: 19.1 - 21.6 °C
- pH: 6.7 - 7.2
- pH adjusted: no
- CEC (meq/100 g): not stated
- Aeration of dilution water: not stated
- Suspended solids concentration: not stated
- Continuous darkness: not stated
- Other:
TEST SYSTEM
- Culturing apparatus: 2000 mL Schott flasks
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: The test vessels were aerated with purified (by activated charcoal), CO2-scrubbed, moistened
air. The scrubbing of carbon dioxide was achieved by bubbling the purified air
through a flask containing 1.5 M NaOH. To control the absence of CO2, the air was then
led through a flask containing a solution of Ba(OH)2 before reaching the test vessels.
- Method used to create anaerobic conditions: not applicable
- Measuring equipment:
- Test performed in closed vessels due to significant volatility of test substance: closed to maintain CO2 free aeration
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: The emitted CO2 was trapped in 0.25 M NaOH. Two scrubbers containing 100 mL each
were connected in series to the test vessels. The initial IC value of the 0.25 M NaOH was
separately determined in each flask.
- Other:
SAMPLING
- Sampling frequency:
- Sampling method:
- Sterility check if applicable:
- Sample storage before analysis:
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank:
- Abiotic sterile control:
- Toxicity control:
- Other:
STATISTICAL METHODS:
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- not performed
- Test performance:
- Validity criteria:
Parameter Criterion Found Assessment
IC content of test item solution in medium <= 5% of TC > 5% *see below
CO2 emitted by the controls < 70 mg/L 13.2 mg/L valid
Difference within replicates <= 20% 1.2 % valid
Degradation of positive control > 60% ≤ 14 days 7 days valid
Degradation in the toxicity flask on day 14 > 25% 26 % valid
*The IC content of test item in medium was more than 5 % of TC as demanded in the
guideline. This is due to the fact that the test item is very poorly soluble in water. Therefore,
this validity criterion is not applicable for the test item.
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- The test item DENACOL EX-147 is considered as “not readily biodegradable“.
For the test item DENACOL EX-147 no biodegradation was observed after 28 days.
The 10-day window could not be determined. The criterion of reaching 60% of degradation
after 28 days was not met.
Abiotic degradation was not observed.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- DENACOL EX-147 is considered as “not readily biodegradable”.
- Executive summary:
The test item DENACOL EX-147 was tested using a concentration of nominally 20 mg organic
carbon/L (corresponding to 56.9 mg/L test item) in test medium following OECD
301B and EU-Method C.4-C.
Aniline was chosen as positive control.
Activated sludge was used as inoculum (concentration in the test 25.0 mg dry matter/L).
The test was left running for 28 days.
All validity criteria were met. Degradation of the positive control was 62 % after 7 days.
The following data were determined for the test item DENACOL EX-147:
10-day-window: not detected
degradation at the end of 10-day-window none
degradation at the end of the test 0 %
pass level following guideline: 60% at the end of 10-day-window for pure substances
respective 60 % at the end of the test for mixtures
For the test item DENACOL EX-147 no biodegradation was observed after 28 days. The
10-day window could not be determined. The criterion of reaching 60% of degradation after
28 days was not met. DENACOL EX-147 is therefore considered as “not readily biodegradable”.
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