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EC number: 202-908-4 | CAS number: 101-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: according to GLP and according to guideline but tested above solubility and vehicle was used. Not clear if test substance caused adverse effects or the undissolved particles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Details on test material:
- - Physical state: liquid
- Storage condition of test material: room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Composite samples of each test concentration were drawn by mixing identical volumes of the test solutions taken from the approximate center of the test vessels. They were taken immediately before exposure and after 48 hours exposure and kept at - 18°C to-22"C until analysis.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Concentration of vehicle in test medium (stock solution and final test solution): 50.9 mg test substance and 2 ml of a TWEEN 80 solution in water (0.1% w/w) were mixed by polytron for 5 minutes and made up to 500 ml with water.
Calculated amounts of the stock solution to produce the desired test concentrations and vehicle to achieve identical vehicle concentrations were given into the
water and were homogeneously distributed. After an equilibration time of 24 hours, the daphnia were transferred into the beakers.
- Evidence of undissolved material (e.g. precipitate, surface film, etc):
The test concentration 10 mg/l was visibly above the limit of solubility. Inspite this fact the test substance was homogeneously distributed in the test vessels at all test times and test concentrations.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain: Straus 1820
- Source: Ciba-Geigy Ltd testing facility
- Age at study initiation (mean and range, SD): 0-24h (separated 24h before begin of exposure)
- Length at study initiation (length definition, mean, range and SD): 800 microm
- Method of breeding: Cultures of daphnia are maintained in glass vessels containing approx. 2.5 1 of reconstituted water (see below) at 20 ± 1 °C (water is renewed partially thrice weekly). At each renewal the daphnia are fed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food is consumed after 24h.
Pre-treatment:
24 hours before the begin of the exposure reproductive daphnia are separated from the young by sieving all individuals through a 800 |.im sieve.
This operation is repeated immediately before the exposure and the young (0-24h of age) are retained for the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20-23°C
- pH:
- 8-8.1
- Dissolved oxygen:
- measured at: 0, 48h
99-100% - Nominal and measured concentrations:
- nominal: 0.58,1.0,1.8, 3.2, 5.8 and 10 mg test substance/l
measured (start of exposure)0.50, 0.86,1.58, 2.75, 5.12 and 8.54 mg/l
measured (end of exposure): 0.43, 0.74,1.39, 2.51,4.57 and 8.08 mg/l
measured (mean): 0.47, 0.80,1.49, 2.63, 4.85, 8.31 mg test substance /I
blank: water
vehicle: 0.4 mg polyoxy-ethylene-sorbitan-monooleate (TWEEN80) - Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers covered with watch glasses
- Fill volume: 100mL
- Aeration: none
TEST MEDIUM / WATER PARAMETERS
reconstituted water containing
65 mg NaHCO3
294 mg CaCl2 x 2 H2O
123 mg MgSO4 x 7 H2O
6 mg KCl
in 1000 ml bidistilled water.
Total hardness: 240 mg CaCOa/l
The water was aerated with clean air for at least 24 hours before use.
- Intervals of water quality measurement: The oxygen content, pH and temperature were measured at 0 and 48 hours.
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily approx. 1500 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Immobilizations were recorded after 24 and 48 hours exposure
TEST CONCENTRATIONS
- Results used to determine the conditions for the definitive study: Pretests showed that the EC 50 will be between 0.58 and 10 mg/I.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.94 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mobility
- Remarks on result:
- other: calculated and graphically determined
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 16.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mobility
- Remarks on result:
- other: calculated
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 8.31 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mobility
- Remarks on result:
- other: observed
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- < 0.47 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mobility
- Remarks on result:
- other: observed
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 0.48 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mobility
- Remarks on result:
- other: observed
- Details on results:
- The test concentration 10 mg/l was visibly above the limit of solubility. Inspite this fact the test substance was homogeneously distributed in the test vessels at all test times and test concentrations.
The actual test concentrations were within 80± 20% of the nominal concentrations, therefore following values were calculated based on actual mean
concentrations: 0.47, 0.80,1.49, 2.63, 4.85 and 8.31 mg/l.
The EC-50 values were calculated according to BERKSON,JASA 48 (1953), 569- 599. EC-values were graphically determined on gausso-Iogarithmic paper
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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