Registration Dossier
Registration Dossier
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EC number: 219-075-8 | CAS number: 2349-07-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct. 2018 - Febr. 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Improved OECD 105 water solubility test design,
Paul Thomas & Virginie Burosse,
CEHTRA Consultancy for Environmental and Human Toxicology and Risk Assessment, Lyon - GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 58.21 mg/L
- Conc. based on:
- act. ingr. (dissolved fraction)
- Loading of aqueous phase:
- 58.21 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 6.88 - <= 6.93
- Conclusions:
- The concentration of hexyl isobutyrate in water was determined in a test according to OECD 105 resp. EU A.6 to be 58.21 ± 7.71 mg/L at 20.0 ± 0.5 °C and pH 6.88 – 6.93.
Reference
The results of the determination are given in the following table (mean of 3 replicates):
Table 1
|
|
Hexylisobutyrate R concentration mg/l |
||||
pH-Value |
3 days |
4 days |
5 days |
6 days |
7 days |
|
Mean |
6.88-6.93 |
55.99 |
62.34 |
60.82 |
46.72 |
62.98 |
Extraordinary observations were not made.
The final result was calculated from the mean of the last 4 replicates.
Mean water solubility (n=4): 58.21 mg/L
Standard deviation (n=4): 7.71mg L
Coefficient of variation (n=4): 13.25 %
Water solubility: 58.21 ± 7.71 mg/L
Description of key information
The concentration of hexyl isobutyrate in water was determined in a test according to OECD 105 resp. EU A.6 to be 58.21 ± 7.71 mg/L at 20.0 ± 0.5 °C and pH 6.88 – 6.93.
Key value for chemical safety assessment
- Water solubility:
- 58.21 mg/L
- at the temperature of:
- 20 °C
Additional information
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