Titanium, diethylene glycol ethylene glycol triisopropanolamine complexes

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Principles of method if other than guideline:

Initial observations showed rapid degradation in minutes in diluted form
Only performed at 'natural' unbuffered pH 4.4; it is known that pH does not influence the rate of degradation of these highly unstable substances
The volatiles could be detected by analyzing the evaporates from the hydrolyzed The Test Substance by GC chromatograms.
The TIPA content in The Test Sample was very small, therefore, analysing the DEG, EG and PG content degraded from the test substance would indicate the hydrolysis, which was measured by comparing the peak area in GC chromatograms.

GLP compliance:

no

Remarks:

The hydrolysis rate is too fast and rigorous guideline test is not possible.

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Supplier: Borica Co., Ltd.
- Lot number: 000534P
- Expiration date of the lot/batch: 2018-Mar-04
- CAS number: 68784-47-4

Radiolabelling:

no

Analytical monitoring:

yes

Duration:

30 min

pH:

4.4

Temp.:

25 °C

Initial conc. measured:

ca. 0.1 g/L

Number of replicates:

2

Preliminary study:

The diluent could be further diluted till 1:1000 in DI water and the appearance observed become cloudy in 30 minutes. The observation was done in duplicate to confirm the hydrolysis status.

Transformation products:

yes

No.:

#1

No.:

#2

No.:

#3

No.:

#4

No.:

#5

Details on hydrolysis and appearance of transformation product(s):

Cloudy appearance on dilution in water as titanium dioxide precipitated out

pH:

4.4

Temp.:

25 °C

DT50:

<= 30 min

Validity criteria fulfilled:

not applicable

Conclusions:

The target substance degradeed rapidly when diluted in water, with formation of titanium dioxide as a precipitate within minutes. Half-life not possible to measure, but considered to be less than 30 minutes.

The recorded degradation products are titanium dioxide, propan-2-ol, triisopropanolamine, diethylene glycol and ethylene glycol. The organic products are known to biodegrade readily.

Key value for chemical safety assessment

Half-life for hydrolysis:

30 min

at the temperature of:

25 °C

Additional information

The recorded hydrolyisis products include inorganic part and organic parts. The inorganic part is titanium dioxide. The organic parts are ethylene glycol, diethylene glycol, triisopropanolamine and 2 -propanol. The organic products are known to biodegrade readily.