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EC number: 908-114-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- acceptable data, no GLP, TS purity not specified
- Justification for type of information:
- This information is used for read-across to Citronellyl Acetate Multi
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- acceptable data, no GLP, TS purity not specified
- Justification for type of information:
- This information is used for read-across to Citronellyl Acetate Multi.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 – 3.1 kg
- Observation period before study: 7 d
- Housing: individually in hanging rabbit cages
- Food and water: ad libitum - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 24 h before the dermal applications: an area on the backs of the animals was shaved (ca. 30% of total body surface), animals were returned to the cages to allow the stratum corneum to recover
- Type of wrap: impervious plastic secured with tape
TEST MATERIAL
- Concentration (if solution): undiluted test material
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, initial and final body weight, behavioral abnormalities, skin reactions - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 0/4 deaths
- Clinical signs:
- other: no effects; no behavioral abnormalities
- Gross pathology:
- no gross findings at necropsy
- Other findings:
- Local skin reactions:
after 24 h: irritant effects - definite red erythema, mild edema
after 6 d: superficial escharosis
end of the 14-day observation period: sloughing - Interpretation of results:
- other: Not acutely harmful
- Remarks:
- according to EU CLP (EC No. 1272/2008, and its amendments).
- Conclusions:
- The dermal acute LD50 is >2000 mg/kg bw in male and female rats.
- Executive summary:
Dermal acute toxicity data are available from a study comparable to guideline (OECD 402) with acceptable restrictions (Reliability 2). In this study 2 rabbits/sex were administered a single dose of 2000 mg/kg bw (undiluted test material) on shaved skin wrapped in an occlusive material. Exposure duration was 24 hours and was followed by a 14-day observation period. Examinations included, mortality, initial and final body weight, behavioural abnormalities, and skin reactions. Necropsy of animals found dead during the test and of survivors was performed. No mortality or other signs of toxicity were observed throughout the test. Local skin reactions included definite red erythema and mild edema after 24 h, superficial escharosis after 6 days, and sloughing at end of the 14-day observation period. Based on these findings, the acute dermal LD50 is >2000 mg/kg bw in male and female rats.
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across information.
- Justification for type of information:
- The read-across justification is presented in the Endpoint summary Acute toxicity. The accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 800 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: read-across from Citronellyl Acetate ('mono')
- Interpretation of results:
- other: Not acutely harmful
- Remarks:
- according to EU CLP (EC No. 1272/2008, and its amendments).
- Conclusions:
- The oral acute toxicity is 6800 mg/kg bw in male and female rats, based on the results of the source substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- acute oral toxicity study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Citronellyl acetate
- EC Number:
- 205-775-0
- EC Name:
- Citronellyl acetate
- Cas Number:
- 150-84-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 16 h
TEST ANIMALS
- Weight at study initiation: 150 - 208 g
- Acclimation period: 5 d before beginning of study
- Housing: stock cages
- Housing after dosing: individually in wire-mesh cages
- Food and water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3000, 4600, 6800, 10200 mg/kg bw
- No. of animals per sex per dose:
- 2 male and 2 female per dose
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, clinical signs, initial and final body weight - Statistics:
- Weil and Thompson methods
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 800 mg/kg bw
- Remarks on result:
- other: Standard deviation: ± 800 mg/kg bw
- Mortality:
- 3000 mg/kg bw: 0/4 deaths
4600 mg/kg bw: 0/4 deaths
6800 mg/kg bw: 2/4 deaths
10200 mg/kg bw: 4/4 deaths - Clinical signs:
- other: 3000 mg/kg: hypoactivity, ruffed fur 4600 mg/kg bw: hypoactivity, ruffed fur, muscular weakness 6800 mg/kg bw: hypoactivity, muscular weakness, prostration, diarrhea, ruffed fur 10200 mg/kg bw: hypoactivity, muscular weakness, prostration, diarrhea, ruffe
- Gross pathology:
- Animals sacrificed: no gross findings
Animals found dead: gastroenteritis, pale livers, pale kidneys, hemorrhages in the stomachs
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acutely harmful
- Remarks:
- according to according to EU CLP (EC No. 1272/2008, and its amendments).
- Conclusions:
- The oral acute toxicity is 6800 mg/kg bw in male and female rats.
- Executive summary:
Oral acute toxicity data are available from a study comparable to guideline (OECD 401) with acceptable restrictions. In this study 2 animals/sex were administered doses of 3000, 4600, 6800, and 10200 mg/kg bw via gavage (no vehicle) and observed for 14 days. Observations included mortality, clinical signs, and initial and final body weights. At the end of the study, necropsy of survivors was performed. At doses of 6800 and 10200 mg/kg bw, mortality was 50% and 100%, respectively. At low doses hypoactivity and ruffed fur was recorded, at higher doses symptoms included also muscular weakness, prostration, and diarrhoea. No evident effect on body weights was observed in survivors. Post-mortem necropsy of survivors revealed no gross pathology. Animals found dead during the test showed gastroenteritis, pale livers, pale kidneys, and haemorrhages in the stomachs. Based on these findings, the acute oral LD50 is 6800 mg/kg bw.
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