Registration Dossier
Registration Dossier
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EC number: 431-090-3 | CAS number: 190085-41-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert review
- Adequacy of study:
- key study
- Study period:
- April 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
- Reference Type:
- publication
- Title:
- A toxicological and dermatologic assessment of salicylates when used as fragrance ingredients
- Author:
- Belsito, D., Bickers, D., Bruze, M., Calow, P., Greim, H., Hanifin, J.M., Rogers, A.E., Saurat, J.H., Sipes, I.G., and Tagami, H.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45:S318-S361
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Profile: Long Chain Alcohols (C6-C22 primary aliphatic alcohols)
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- SIAM 22, April 18-21
Materials and methods
- Objective of study:
- other: Expert review and summary of available information
- Principles of method if other than guideline:
- Expert review of the toxicokinetic properties of the subject material based on physical-chemical parameters and available published information.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 431-090-3
- EC Name:
- -
- Cas Number:
- 190085-41-7
- Molecular formula:
- C19 H30 O3
- IUPAC Name:
- 2-butyloctyl 2-hydroxybenzoate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable
Administration / exposure
- Route of administration:
- other: oral, dermal and inhalation
- Details on exposure:
- See information in this endpoint summary
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Once absorbed from the GI tract, lungs or skin, the subject material is expected to be rapidly metabolized and eliminated predominantly through the urine. As conservative estimates, oral and inhalation bioavailability are presumed to be 100%. Based on the physical-chemical properties of the subject material as well as on data for similar salicylate esters, dermal absorption through human skin should be minimal. A conservative estimate of 10% dermal absorption is assigned.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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